Giuntoli F, Galeone F, Gabbani S, Spagnolo G, Brunelleschi G, Natali A, Gallo Stampino C, Saba P
Department of Internal Medicine, Hospital of Valdinievole, Pistoia, Italy.
Clin Ther. 1990 Sep-Oct;12(5):421-6.
The subjects were 15 patients, aged 53 to 74 years, with noninsulin-dependent diabetes mellitus and mild to moderate hypertension. Each received 20 to 40 mg of nitrendipine daily for six months. Mean supine blood pressures decreased significantly from 177/102 mmHg before treatment to 164/95 mmHg at three months and continued to decline during the following three months. Diastolic blood pressure was reduced to less than 90 mmHg in eight of the 15 patients. No changes in heart rate, glycemic control (serum levels of glucose, C-peptide, glycosylated hemoglobin, and fructosamine), or serum lipid levels (cholesterol and its lipoprotein fractions, triglycerides, and apolipoproteins A1 and B) were noted. It is concluded that nitrendipine is safe and effective in the treatment of hypertension in diabetic patients.
研究对象为15例年龄在53至74岁之间的非胰岛素依赖型糖尿病合并轻至中度高血压患者。每人每天服用20至40毫克尼群地平，持续六个月。平均仰卧血压从治疗前的177/102毫米汞柱显著降至三个月时的164/95毫米汞柱，并在接下来的三个月中持续下降。15例患者中有8例舒张压降至90毫米汞柱以下。未观察到心率、血糖控制（血清葡萄糖、C肽、糖化血红蛋白和果糖胺水平）或血脂水平（胆固醇及其脂蛋白组分、甘油三酯以及载脂蛋白A1和B）有变化。得出结论，尼群地平治疗糖尿病患者高血压安全有效。
