Palermo R, Conti V, Agostinelli M C, Ganzetti S, Racco F, Melappioni A, Pratillo G, Moretti S
Cardiologic Service, Local Health Care Unit No. 10, Iesi, Italy.
Clin Ther. 1990 Mar-Apr;12(2):149-56.
Twenty-four patients with mild to moderate hypertension were randomly assigned to 42 days of treatment with 20 mg of nitrendipine once daily or 20 mg of nicardipine thrice daily. In the nitrendipine-treated and nicardipine-treated patients, respectively, mean resting blood pressure decreased from 163 +/- 12 and 161 +/- 11 mmHg at baseline to 152 +/- 12 and 146 +/- 9 mmHg at six weeks (P less than 0.001). Blood pressures were reduced after one day of treatment, followed by an attenuation of the drug effect. In both treatment groups, blood pressures after cycloergometric, isometric, and cold-pressure tests were significantly lower at six weeks than at baseline; at six weeks, blood pressures were also significantly reduced two hours after drug administration, compared with those at or just before drug administration. It is concluded that nitrendipine taken once daily is safe and effective in the treatment of mild to moderate hypertension.
24例轻至中度高血压患者被随机分配，分别接受为期42天的治疗，其中一组每日服用一次20毫克尼群地平，另一组每日服用三次20毫克尼卡地平。在尼群地平治疗组和尼卡地平治疗组中，平均静息血压分别从基线时的163±12和161±11毫米汞柱降至六周时的152±12和146±9毫米汞柱（P<0.001）。治疗一天后血压即下降，随后药物效果有所减弱。在两个治疗组中，六周时进行踏车运动试验、等长运动试验和冷压试验后的血压均显著低于基线水平；六周时，给药两小时后的血压与给药时或给药前相比也显著降低。结论是，每日服用一次尼群地平治疗轻至中度高血压安全有效。
