测量啮齿动物视网膜电图以评估视网膜功能。

Measuring rodent electroretinograms to assess retinal function.

作者信息

Clark Molly E, Kraft Timothy W

机构信息

Departments of Vision Sciences & Optometry, University of Alabama at Birmingham, Birmingham, AL, USA.

出版信息

Methods Mol Biol. 2012;884:265-76. doi: 10.1007/978-1-61779-848-1_19.

DOI:10.1007/978-1-61779-848-1_19

PMID:22688713

Abstract

Electroretinography is a noninvasive technique used to measure the electrical activity of neurons in the retina. Electroretinogram (ERG) waveforms can be used to quantify retinal function in normal and diseased rodents. In particular, the functions of rod and cone pathways can be isolated. Inner retinal neuronal functioning, such as bipolar cell activity or ganglion cell activity, can also be measured. In this chapter we describe the common full-field ERG techniques of scoptic flash, photopic flash, and flicker used to isolate and compare rod-driven and cone-driven function.

摘要

视网膜电图是一种用于测量视网膜中神经元电活动的非侵入性技术。视网膜电图（ERG）波形可用于量化正常和患病啮齿动物的视网膜功能。特别是，视杆和视锥细胞通路的功能可以被分离出来。视网膜内层神经元的功能，如双极细胞活动或神经节细胞活动，也可以被测量。在本章中，我们描述了用于分离和比较视杆细胞驱动和视锥细胞驱动功能的常见全视野ERG技术，即暗视闪光、明视闪光和闪烁刺激技术。