Spectrométries et Dynamique Moléculaire, Physique des Interactions Ioniques et Moléculaires (UMR CNRS 7345, Université de Provence) - Centre de St Jérôme - case 252, Avenue Escadrille Normandie-Niémen, 13397 Marseille Cedex 20, France.
Chem Soc Rev. 2012 Aug 21;41(16):5416-29. doi: 10.1039/c2cs35064e. Epub 2012 Jun 12.
α-Amino acids are easily accessible through abiotic processes and were likely present before the emergence of life. However, the role they could have played in the process remains uncertain. Chemical pathways that could have brought about features of self-organization in a peptide world are considered in this review and discussed in relation with their possible contribution to the origin of life. An overall scheme is proposed with an emphasis on possibilities that may have led to dynamically stable far from equilibrium states. This analysis defines new lines of investigation towards a better understanding of the contribution of the systems chemistry of amino acids and peptides to the emergence of life.
α-氨基酸可以通过非生物过程轻松获得，并且可能在生命出现之前就已经存在。然而，它们在这一过程中可能扮演的角色仍然不确定。本文回顾了可能在肽世界中带来自组织特征的化学途径，并讨论了它们对生命起源的可能贡献。本文提出了一个总体方案，重点探讨了可能导致远离平衡状态的动态稳定的可能性。这种分析定义了新的研究方向，以更好地理解氨基酸和肽的系统化学对生命出现的贡献。
