Piovesan A, Panarelli M, Terzolo M, Osella G, Matrella C, Paccotti P, Angeli A
Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, Italy.
Chronobiol Int. 1990;7(3):263-5. doi: 10.3109/07420529009056985.
We monitored the circadian profiles of cortisol, systolic and diastolic blood pressure (SBP and DBP) and heart rate (HR) in 33 matched normotensive subjects, 32 patients with essential hypertension and 16 patients with Cushing's Syndrome (8 pituitary adenomas, 6 adrenal adenomas and 2 adrenal carcinomas). Each subject underwent serial blood drawings at 4-hr intervals along the 24-hr cycle. BP and HR were automatically recorded every 30 min. Data were analyzed by conventional statistics and by chronobiological procedures (cosinor rhythmometry). Both the control subjects and essential hypertensives showed a circadian profile of BP and HR characterized by a peak in the early afternoon and a clear nocturnal fall (rhythm detection: P less than 0.001). The rhythmicity of BP was disrupted in patients affected by Cushing's Syndrome, whereas the 24-hr oscillation of HR was preserved (P less than 0.001). Our data are compatible with the view that glucocorticoids are involved in the control of BP circadian rhythm, whereas HR is not under their control.
我们监测了33名匹配的血压正常受试者、32名原发性高血压患者和16名库欣综合征患者（8例垂体腺瘤、6例肾上腺腺瘤和2例肾上腺皮质癌）的皮质醇、收缩压和舒张压（SBP和DBP）以及心率（HR）的昼夜节律。每位受试者在24小时周期内每隔4小时进行一次系列采血。血压和心率每30分钟自动记录一次。数据通过常规统计学方法和时间生物学程序（余弦节律分析）进行分析。对照组受试者和原发性高血压患者的血压和心率昼夜节律均表现为午后早期达到峰值，夜间明显下降（节律检测：P<0.001）。库欣综合征患者的血压节律性被破坏，而心率的24小时振荡仍得以保留（P<0.001）。我们的数据支持以下观点，即糖皮质激素参与血压昼夜节律的调控，而心率不受其控制。
