Imai Y, Abe K, Sasaki S, Minami N, Nihei M, Munakata M, Sekino H, Yoshinaga K
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai.
Tohoku J Exp Med. 1987 Sep;153(1):67-74. doi: 10.1620/tjem.153.67.
The circadian rhythm of blood pressure (BP) was compared between patients with Cushing's syndrome and those with essential hypertension. In patients with essential hypertension, clear nocturnal falls in systolic and diastolic BP and heart rate (HR) were observed, and there was a positive correlation between HR and systolic or diastolic BP. On the other hand, in patients with Cushing's syndrome, there was no nocturnal fall in BP and instead a rise in some cases. In all cases with Cushing's syndrome there was a nocturnal fall in HR, and consequently no significant correlation between HR and BP in these patients. The present results imply that the normal circadian rhythm of blood pressure may be regulated at least in part by the hypothalamo-pituitary-adrenal system.
比较了库欣综合征患者与原发性高血压患者的血压昼夜节律。在原发性高血压患者中，观察到收缩压和舒张压以及心率在夜间明显下降，且心率与收缩压或舒张压之间存在正相关。另一方面，在库欣综合征患者中，血压没有夜间下降，反而在某些情况下有所上升。在所有库欣综合征病例中，心率在夜间下降，因此这些患者的心率与血压之间无显著相关性。目前的结果表明，正常的血压昼夜节律可能至少部分受下丘脑 - 垂体 - 肾上腺系统调节。
