Girls College of Science, University of King Abdul Aziz, Jeddah, Saudi Arabia.
Biol Res. 2012;45(1):15-20. doi: 10.4067/S0716-97602012000100002.
Alkylphenol polyethoxylates is a group of estrogenic compounds. Natural or synthetic types of these compounds react with the endocrine system by binding hormone receptors, resulting in interference with their action, which is why they are called endocrine disrupting chemicals. Among their hydrolytic products are nonylphenols (NP), which are considered pollutants of aquatic environments. The objective of this study was to evaluate the pathological alterations on liver tissue of fish exposed to these compounds for long durations, starting from beginning of life and during the period of sexual maturity. Tilapia fish were obtained from Abhur fish farms, reared in the laboratory in special basins, and divided into two groups. The first maternal group was untreated and their larvae were divided into three sub-groups: control; exposed to 15μg/L; and exposed to 30 μg/L. The second maternal group was divided into 2 sub-groups: with larvae exposed to 15μg/L; and with their larvae exposed to 30 μg/L. Larvae and mother exposed to different concentrations of NP (15 and 30 μg/L) showed an increased accumulation of NP in both livers and muscles compared to the control group due to bioaccumulation. Tissue section examinations of the treated group (15 μg NP /L) showed disruption of liver architecture, with lyses, loss of nuclei, necrosis, and fatty infiltration. The changes were more marked in tissues exposed to (30 μg NP /L). Although this pollution was not lethal, its effect may be reflected in vital activities and in the economy.
烷基酚聚氧乙烯醚是一组具有雌激素性质的化合物。这些化合物的天然或合成类型通过与激素受体结合，与内分泌系统发生反应，从而干扰其作用，因此它们被称为内分泌干扰化学物质。它们的水解产物中有壬基酚（NP），被认为是水生环境的污染物。本研究的目的是评估鱼类在生命早期和性成熟期间长期暴露于这些化合物时肝脏组织的病理变化。罗非鱼来自阿布赫鱼养殖场，在实验室的特殊水池中饲养，并分为两组。第一组母鱼未经处理，其幼鱼分为三组：对照组；暴露于 15μg/L；和暴露于 30μg/L。第二组母鱼分为两组：一组幼鱼暴露于 15μg/L；另一组幼鱼暴露于 30μg/L。暴露于不同浓度 NP（15 和 30μg/L）的幼鱼和母鱼由于生物积累，其肝脏和肌肉中的 NP 积累量均高于对照组。经处理组（15μg NP/L）的组织切片检查显示肝脏结构破坏，有溶解、核丢失、坏死和脂肪浸润。暴露于（30μg NP/L）的组织变化更为明显。尽管这种污染没有致命性，但它的影响可能会反映在生命活动和经济上。
