茅苍术的抗缺氧作用及活性成分

Antianoxic action and active constituents of atractylodis lanceae rhizoma.

作者信息

Yamahara J, Matsuda H, Naitoh Y, Fujimura H, Tamai Y

机构信息

Kyoto Pharmaceutical University, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1990 Jul;38(7):2033-4. doi: 10.1248/cpb.38.2033.

DOI:10.1248/cpb.38.2033

PMID:2268908

Abstract

The screening test was carried out to identify new drugs from natural products for the KCN-induced anoxia model in mice. Acetone extract of Atractylodis Lanceae Rhizoma (Atractylodes lancea DC. var. Chinensis Kitamura) had a significant effect in the KCN-induced anoxia model and therefore the extract was selected for further study in order to identify the active principles. The result showed that beta-eudesmol was the active component in Atractylodis Lanceae Rhizoma.

摘要

进行筛选试验以从天然产物中鉴定用于小鼠KCN诱导的缺氧模型的新药。茅苍术（白术北村变种）的丙酮提取物在KCN诱导的缺氧模型中具有显著作用，因此选择该提取物进行进一步研究以确定其活性成分。结果表明，β-桉叶醇是茅苍术的活性成分。