Inserm, CESP Center for research in Epidemiology and Population Health, U1018, Environmental Epidemiology of Cancer, Villejuif, France; Univ Paris-Sud, UMRS 1018, Villejuif, France.
Int J Cancer. 2013 Feb 15;132(4):924-31. doi: 10.1002/ijc.27669. Epub 2012 Jun 26.
Night work involving disruption of circadian rhythm was suggested as a possible cause of breast cancer. We examined the role of night work in a large population-based case-control study carried out in France between 2005 and 2008. Lifetime occupational history including work schedules of each night work period was elicited in 1,232 cases of breast cancer and 1,317 population controls. Thirteen percent of the cases and 11% of the controls had ever worked on night shifts (OR = 1.27 [95% confidence interval = 0.99-1.64]). Odds ratios were 1.35 [1.01-1.80] in women who worked on overnight shifts, 1.40 [1.01-1.92] in women who had worked at night for 4.5 or more years, and 1.43 [1.01-2.03] in those who worked less than three nights per week on average. The odds ratio was 1.95 [1.13-3.35] in women employed in night work for >4 years before their first full-term pregnancy, a period where mammary gland cells are incompletely differentiated and possibly more susceptible to circadian disruption effects. Our results support the hypothesis that night work plays a role in breast cancer, particularly in women who started working at night before first full-term pregnancy.
夜间工作扰乱生物钟被认为是乳腺癌的一个可能病因。我们在法国开展了一项大型基于人群的病例对照研究，调查了夜班工作在其中的作用。该研究于 2005 年至 2008 年进行，在病例组（1232 例乳腺癌患者）和对照组（1317 例一般人群）中，我们收集了包括各次夜班工作时段的终生职业史信息。13%的病例和 11%的对照曾上过夜班（OR=1.27，95%置信区间为 0.99-1.64）。上通宵夜班的女性比值比（OR）为 1.35（1.01-1.80），夜间工作 4.5 年或以上的女性为 1.40（1.01-1.92），每周平均上夜班少于 3 天的女性为 1.43（1.01-2.03）。首次足月妊娠前从事夜班工作超过 4 年的女性的比值比为 1.95（1.13-3.35），这段时期乳腺细胞尚未完全分化，可能更容易受到昼夜节律紊乱的影响。我们的研究结果支持夜班工作与乳腺癌有关的假说，尤其是在首次足月妊娠前开始夜间工作的女性中。
