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[危重症患者心房颤动的治疗]

[Therapy of atrial fibrillation in the critically ill].

作者信息

Willich T, Hammwöhner M, Goette A

机构信息

Medizinische Klinik II, St. Vincenz Krankenhaus Paderborn, Am Busdorf 2, 33098, Paderborn, Deutschland.

出版信息

Med Klin Intensivmed Notfmed. 2012 Jun;107(5):368-76. doi: 10.1007/s00063-012-0082-5. Epub 2012 Jun 13.

DOI:10.1007/s00063-012-0082-5
PMID:22689259
Abstract

Atrial fibrillation (AF) is the most common form of arrhythmia in the intensive care unit (ICU) and is associated with increased mortality. A total of five types of AF can be distinguished: initially diagnosed, paroxysmal, persistent, long-standing persistent and permanent AF. In addition to the initial treatment, antithrombotic therapy, rate and rhythm management can be used. The treatment of comorbidities is part of the patient management and for patients with increased risk of thromboembolic events anticoagulation is recommended. The simplest risk assessment scheme is the CHADS score. In the acute setting rate control is important. Direct current cardioversion is urgently recommended for patients with AF when hemodynamic instability is present even in patients with AF and pre-excitation in Wolff-Parkinson-White syndrome. Pharmacological cardioversion may be considered in patients with AF when hemodynamic stability is present. When choosing the antiarrhythmic agent for critically ill patients only amiodarone can be considered with some exceptions due to the specific contraindications.

摘要

心房颤动(AF)是重症监护病房(ICU)中最常见的心律失常形式,且与死亡率增加相关。AF总共可分为五种类型:初发诊断型、阵发性、持续性、长期持续性和永久性AF。除初始治疗外,还可采用抗栓治疗、心率和节律管理。合并症的治疗是患者管理的一部分,对于血栓栓塞事件风险增加的患者,建议进行抗凝治疗。最简单的风险评估方案是CHADS评分。在急性情况下,心率控制很重要。对于存在血流动力学不稳定的AF患者,即使是患有预激综合征的AF患者,紧急建议进行直流电复律。当血流动力学稳定时,AF患者可考虑药物复律。在为重症患者选择抗心律失常药物时,由于存在特定禁忌证,一般仅可考虑胺碘酮,某些情况除外。

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本文引用的文献

1
[Heart rhythm disturbances and their treatment according to recent recommendations].[根据最新建议的心律失常及其治疗]
Dtsch Med Wochenschr. 2010 Dec;135(49):2461-76; quiz 2477-80. doi: 10.1055/s-0030-1269418. Epub 2010 Nov 30.
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Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC).心房颤动管理指南:欧洲心脏病学会(ESC)心房颤动管理特别工作组
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维纳卡兰:一种用于将心房颤动快速转复为窦性心律的新型抗心律失常药物
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A short-term, randomized, double-blind, parallel-group study to evaluate the efficacy and safety of dronedarone versus amiodarone in patients with persistent atrial fibrillation: the DIONYSOS study.一项评估决奈达隆与胺碘酮治疗持续性心房颤动患者的疗效和安全性的短期、随机、双盲、平行组研究:狄俄尼索斯研究。
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Optimization of initial energy for cardioversion of atrial tachyarrhythmias with biphasic shocks.双相波电击转复房性心动过速的初始能量优化。
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Stroke in paroxysmal atrial fibrillation: report from the Stockholm Cohort of Atrial Fibrillation.阵发性心房颤动中的脑卒中:来自斯德哥尔摩心房颤动队列的报告。
Eur Heart J. 2010 Apr;31(8):967-75. doi: 10.1093/eurheartj/ehn599. Epub 2009 Jan 27.
9
Stroke and thromboembolism in atrial fibrillation: a systematic review of stroke risk factors, risk stratification schema and cost effectiveness data.心房颤动中的中风与血栓栓塞:中风危险因素、风险分层方案及成本效益数据的系统评价
Thromb Haemost. 2008 Feb;99(2):295-304. doi: 10.1160/TH07-08-0508.
10
Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation.用于房颤复律后维持窦性心律的抗心律失常药物。
Cochrane Database Syst Rev. 2007 Oct 17(4):CD005049. doi: 10.1002/14651858.CD005049.pub2.