手性吡咯烷酮双噁唑啉配体-铕(III)配合物催化的烷基 1-茚满酮-2-羧酸酯不对称氟代反应。
Catalytic Asymmetric Fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination.
机构信息
Department of Chemistry, Universitat Autònoma de Barcelona and Centro de Innovación en Química Avanzada (ORFEO-CINQA), Cerdanyola del Vallès, 08193 Barcelona, Spain.
出版信息
Molecules. 2019 Mar 22;24(6):1141. doi: 10.3390/molecules24061141.
Abstract
A highly enantioselective catalytic method for the synthesis of quaternary α-fluoro derivatives of 3-oxo esters is described. The reaction uses europium (III) triflate and commercially available chiral pybox-type C2-symmetric ligand. Excellent results in terms of yields and enantioselectivities were assured using the electrophilic NFSI reagent under mild reaction conditions.
摘要
本文描述了一种高对映选择性催化方法，用于合成 3-氧代酯的季铵 α-氟代衍生物。该反应使用三氟甲磺酸镧和市售的手性 pybox 型 C2 对称配体。在温和的反应条件下，使用亲电 NFSI 试剂，可以确保获得高产率和对映选择性的优异结果。
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