Cowley Anna, Pascoe Sarah
Oncology Department, Plymouth Hospitals NHS Trust, Plymouth, Devon, UK.
BMJ Case Rep. 2011 Jul 28;2011:bcr0420114077. doi: 10.1136/bcr.04.2011.4077.
Paraneoplastic syndromes arise infrequently in prostate cancer and paraneoplastic subacute sensory neuronopathy has not previously been reported in association with prostate cancer. When paraneoplastic syndromes occur, it is usually in the setting of small-cell carcinoma of the prostate or advanced, hormone-resistant disease. Here the authors report a 64- year-old man who developed a progressive, severe, sensory neuronopathy in the setting of a recently diagnosed stage T4 hormone-responsive prostate adenocarcinoma. Anti-Hu antibodies were positive and screening for a concurrent neoplasm at another site was negative. Sensory neuronopathy progressed, despite hormone responsiveness of his prostate adenocarcinoma, and resulted in a severe level of disability. His symptoms did not respond to intravenous corticosteroid therapy but there was a partial response to intravenous immunoglobulin.
副肿瘤综合征在前列腺癌中很少见，此前尚未有副肿瘤性亚急性感觉神经元病与前列腺癌相关的报道。当出现副肿瘤综合征时，通常发生在前列腺小细胞癌或晚期激素抵抗性疾病的情况下。本文作者报告了一名64岁男性，在最近诊断为T4期激素反应性前列腺腺癌的情况下，出现了进行性、严重的感觉神经元病。抗Hu抗体呈阳性，对另一部位同时发生肿瘤的筛查为阴性。尽管他的前列腺腺癌对激素有反应，但感觉神经元病仍在进展，并导致严重残疾。他的症状对静脉注射皮质类固醇治疗无反应，但对静脉注射免疫球蛋白有部分反应。
