Lemmens H J, Burm A G, Hennis P J, Gladines M P, Bovill J G
Department of Anesthesiology, University Hospital Leiden, The Netherlands.
Clin Pharmacokinet. 1990 Nov;19(5):416-22. doi: 10.2165/00003088-199019050-00005.
Studies on the effects of age on the pharmacokinetics of alfentanil are inconclusive. A possible factor in explaining the differences between various studies could be the effect of gender. The authors studied the effects of age on the pharmacokinetics of alfentanil in female (n = 21) and male (n = 15) patients undergoing lower abdominal surgery under nitrous oxide alfentanil anaesthesia. There was a significant negative correlation (r = -0.79, p less than 0.001) between plasma alfentanil clearance (CL) and age in women (less than 50y, median CL 24.84 L/h; greater than 50y, median CL 14.52 L/h), but not in men (less than 50y, median CL 19.44 L/h; greater than 50y, median CL 16.2 L/h). The conclusion is drawn that the effects of age on the pharmacokinetics of alfentanil are gender-dependent.
关于年龄对阿芬太尼药代动力学影响的研究尚无定论。解释不同研究之间差异的一个可能因素是性别影响。作者研究了年龄对接受氧化亚氮-阿芬太尼麻醉下腹部手术的女性（n = 21）和男性（n = 15）患者阿芬太尼药代动力学的影响。女性患者血浆阿芬太尼清除率（CL）与年龄之间存在显著负相关（r = -0.79，p小于0.001）（年龄小于50岁，CL中位数为24.84 L/h；年龄大于50岁，CL中位数为14.52 L/h），而男性患者则无此相关性（年龄小于50岁，CL中位数为19.44 L/h；年龄大于50岁，CL中位数为16.2 L/h）。得出的结论是，年龄对阿芬太尼药代动力学的影响具有性别依赖性。
