Lemmens H J, Bovill J G, Hennis P J, Burm A G
Department of Anesthesiology, University Hospital, Leiden, The Netherlands.
Anesth Analg. 1988 Oct;67(10):956-60.
Effects of age on the pharmacodynamics of alfentanil, as a supplement to nitrous oxide anesthesia, were studied in younger (31-52 years; n = 14) and older (56-86 years; n = 14) women undergoing curative surgery for primary breast cancer. Plasma alfentanil concentration-effect curves for perioperative stimuli and for the probability of needing naloxone at the end of the operation were fitted by logistic regression. Effects of age on the plasma concentration-effect relation of alfentanil could not be demonstrated. However, the dose requirement in the older patient group was significantly lower than in the younger patient group.
作为一氧化二氮麻醉的补充，研究年龄对阿芬太尼药效学的影响，研究对象为接受原发性乳腺癌根治性手术的年轻女性（31 - 52岁；n = 14）和年长女性（56 - 86岁；n = 14）。通过逻辑回归拟合围手术期刺激的血浆阿芬太尼浓度 - 效应曲线以及手术结束时需要纳洛酮的概率。未证实年龄对阿芬太尼血浆浓度 - 效应关系的影响。然而，老年患者组的剂量需求显著低于年轻患者组。
