Chandolu Vijay, Dass Crispin R
School of Biomedical and Health Sciences, Victoria University, Building 6, St Albans, VIC 3021, Australia.
J Biomed Biotechnol. 2012;2012:740295. doi: 10.1155/2012/740295. Epub 2012 May 28.
Cancer is becoming an increasingly common disease in which abnormal cells aggressively grow, invade, and metastasize. In this paper, we review the biological functions of PEDF (pigmented epithelium-derived factor) against cancer, with a focus on a particular type of bone cancer called osteosarcoma. PEDF is a 50 kDa glycoprotein and is a potent inhibitor of angiogenesis, via its ability to decrease proliferation and migration of endothelial cells. This paper critically examines the anticancer activities of PEDF via its role in antiangiogenesis, apoptosis-mediated tumor suppression, and increased tumor cell differentiation. Recently, an orthotopic model of osteosarcoma was used to show that treatment with PEDF had the greatest impact on metastases, warranting an evaluation of PEDF efficacy in other types of cancers.
癌症正成为一种日益常见的疾病，其中异常细胞会迅速生长、侵袭和转移。在本文中，我们综述了色素上皮衍生因子（PEDF）对抗癌症的生物学功能，重点关注一种称为骨肉瘤的特定类型骨癌。PEDF是一种50 kDa的糖蛋白，通过降低内皮细胞的增殖和迁移能力，是一种有效的血管生成抑制剂。本文通过PEDF在抗血管生成、凋亡介导的肿瘤抑制以及增加肿瘤细胞分化中的作用，批判性地研究了其抗癌活性。最近，一种骨肉瘤原位模型被用于表明用PEDF治疗对转移有最大影响，这使得有必要评估PEDF在其他类型癌症中的疗效。
