色素上皮衍生因子的应用生物化学及其对组织稳态的影响。
The applied biochemistry of PEDF and implications for tissue homeostasis.
作者信息
Broadhead Matthew L, Becerra S Patricia, Choong Peter F M, Dass Crispin R
机构信息
Department of Orthopaedics, St Vincent's Hospital, University of Melbourne, Melbourne, Vic., Australia.
出版信息
Growth Factors. 2010 Aug;28(4):280-5. doi: 10.3109/08977191003604513.
Abstract
Pigment epithelium-derived factor (PEDF) is an endogenously produced glycoprotein with a spectrum of biological roles across diverse pathologies. Recent research has focused on the biochemical properties of PEDF and its associated receptors. This review discusses the recent developments in PEDF biochemistry and how this new knowledge will help progress our understanding of PEDF as a molecular mediator for anti-angiogenesis and -tumorigenesis. Additionally, pathophysiological roles for PEDF in healing and tissue homeostasis are being revealed and our enhanced understanding of the interactions between PEDF and its receptors may yet prove useful in propelling PEDF towards clinical application.
摘要
色素上皮衍生因子（PEDF）是一种内源性产生的糖蛋白，在多种病理过程中具有一系列生物学作用。最近的研究集中在PEDF及其相关受体的生化特性上。本综述讨论了PEDF生物化学的最新进展，以及这些新知识将如何帮助我们进一步理解PEDF作为抗血管生成和抗肿瘤发生的分子介质。此外，PEDF在愈合和组织稳态中的病理生理作用正在被揭示，我们对PEDF与其受体之间相互作用的深入理解可能最终有助于推动PEDF走向临床应用。
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