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A case of synchronous pancreatic ductal adenocarcinoma and ovarian mucinous cystic neoplasm: use of kras mutation molecular phenotyping to demonstrate independent primary origin.一例同步性胰腺导管腺癌和卵巢黏液性囊性肿瘤：利用KRAS突变分子表型分析证明独立的原发起源
Gastrointest Cancer Res. 2012 Mar;5(2):67-70.
2
Preoperative GNAS and KRAS testing in the diagnosis of pancreatic mucinous cysts.术前 GNAS 和 KRAS 检测在胰腺黏液性囊腺瘤/囊腺癌诊断中的应用。
Clin Cancer Res. 2014 Aug 15;20(16):4381-9. doi: 10.1158/1078-0432.CCR-14-0513. Epub 2014 Jun 17.
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and mutations synergistically induce intraductal papillary mucinous neoplasm derived from pancreatic duct cells.并且突变协同诱导源自胰腺导管细胞的导管内乳头状黏液性肿瘤。
Gut. 2020 Apr;69(4):704-714. doi: 10.1136/gutjnl-2018-318059. Epub 2019 Jun 1.
4
Molecular mechanism of intraductal papillary mucinous neoplasm and intraductal papillary mucinous neoplasm-derived pancreatic ductal adenocarcinoma.导管内乳头状黏液性肿瘤及导管内乳头状黏液性肿瘤衍生的胰腺导管腺癌的分子机制
J Hepatobiliary Pancreat Sci. 2015 Jul;22(7):519-23. doi: 10.1002/jhbp.246. Epub 2015 Apr 21.
5
Loss of Pten and Activation of Kras Synergistically Induce Formation of Intraductal Papillary Mucinous Neoplasia From Pancreatic Ductal Cells in Mice.PTEN 缺失和 Kras 激活协同诱导小鼠胰腺导管细胞形成导管内乳头状黏液性肿瘤。
Gastroenterology. 2018 Apr;154(5):1509-1523.e5. doi: 10.1053/j.gastro.2017.12.007. Epub 2017 Dec 19.
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Invasive Ductal Carcinoma Arising in Mucinous Cystic Neoplasm of Pancreas: A Case Report.胰腺黏液性囊性肿瘤中发生的浸润性导管癌：一例报告
Am J Case Rep. 2019 Feb 24;20:242-247. doi: 10.12659/AJCR.914092.
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Histo-molecular oncogenesis of pancreatic cancer: From precancerous lesions to invasive ductal adenocarcinoma.胰腺癌的组织分子肿瘤发生：从前体病变到浸润性导管腺癌。
World J Gastrointest Oncol. 2018 Oct 15;10(10):317-327. doi: 10.4251/wjgo.v10.i10.317.
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Characterisation of oestrogen receptor, progesterone receptor, trefoil factor 1, and epidermal growth factor and its receptor in pancreatic cystic neoplasms and pancreatic ductal adenocarcinoma.雌激素受体、孕激素受体、三叶因子1、表皮生长因子及其受体在胰腺囊性肿瘤和胰腺导管腺癌中的特征分析
Gut. 2002 Nov;51(5):712-6. doi: 10.1136/gut.51.5.712.
9
TP53 mutations are common in all subtypes of epithelial ovarian cancer and occur concomitantly with KRAS mutations in the mucinous type.TP53 突变在所有上皮性卵巢癌亚型中都很常见，并且与黏液型中的 KRAS 突变同时发生。
Exp Mol Pathol. 2013 Oct;95(2):235-41. doi: 10.1016/j.yexmp.2013.08.004. Epub 2013 Aug 18.
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SATB2 Expression Distinguishes Ovarian Metastases of Colorectal and Appendiceal Origin From Primary Ovarian Tumors of Mucinous or Endometrioid Type.SATB2表达可区分结直肠和阑尾来源的卵巢转移瘤与黏液性或子宫内膜样型原发性卵巢肿瘤。
Am J Surg Pathol. 2016 Mar;40(3):419-32. doi: 10.1097/PAS.0000000000000553.

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1
Pancreatic cyst endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA): Benign or malignant. Clues to cytological diagnosis with major consequences.胰腺囊肿内镜超声引导下细针穿刺活检（EUS-FNA）：良性还是恶性。对具有重大影响的细胞学诊断的线索。
Cytojournal. 2022 Apr 2;19:26. doi: 10.25259/Cytojournal_11_2021. eCollection 2022.
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Isolated Ovarian Metastasis from Pancreatic Cancer Mimicking Primary Ovarian Neoplasia: Role of Molecular Analysis in Determining Diagnosis.酷似原发性卵巢肿瘤的胰腺癌孤立性卵巢转移：分子分析在确定诊断中的作用
J Pancreat Cancer. 2021 Oct 14;7(1):74-79. doi: 10.1089/pancan.2021.0001. eCollection 2021.
3
Ovarian metastases of pancreatic adenocarcinoma: clinical presentation, role of surgery, and potential value of the mutational profile for the differential diagnosis with primary mucinous ovarian carcinoma.胰腺腺癌的卵巢转移：临床表现、手术作用以及突变谱在与原发性黏液性卵巢癌鉴别诊断中的潜在价值。
Ther Adv Med Oncol. 2021 Oct 26;13:17588359211053412. doi: 10.1177/17588359211053412. eCollection 2021.
4
Synchronous primary adenocarcinoma of the lung and pancreas: a case series and review of the literature.肺与胰腺同步原发性腺癌：病例系列及文献综述
Lung Cancer Manag. 2017 Jul;6(1):17-23. doi: 10.2217/lmt-2017-0003. Epub 2017 Jul 14.

本文引用的文献

1
KRAS mutation analysis in ovarian samples using a high sensitivity biochip assay.使用高灵敏度生物芯片检测法对卵巢样本进行KRAS突变分析。
BMC Cancer. 2009 Apr 9;9:111. doi: 10.1186/1471-2407-9-111.
2
DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer.原发性癌的DPC4基因状态与胰腺癌患者的复发模式相关。
J Clin Oncol. 2009 Apr 10;27(11):1806-13. doi: 10.1200/JCO.2008.17.7188. Epub 2009 Mar 9.
3
Morphogenesis of pancreatic cancer: role of pancreatic intraepithelial neoplasia (PanINs).胰腺癌的形态发生：胰腺上皮内瘤变（PanINs）的作用。
Langenbecks Arch Surg. 2008 Jul;393(4):561-70. doi: 10.1007/s00423-008-0282-x. Epub 2008 Feb 19.
4
Clinicopathologic features and treatment strategies for patients with pancreatic adenocarcinoma and ovarian metastases.胰腺腺癌伴卵巢转移患者的临床病理特征及治疗策略
Gynecol Oncol. 2008 Mar;108(3):515-9. doi: 10.1016/j.ygyno.2007.11.012.
5
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer.靶向Raf-MEK-ERK丝裂原活化蛋白激酶级联反应用于癌症治疗。
Oncogene. 2007 May 14;26(22):3291-310. doi: 10.1038/sj.onc.1210422.
6
From krukenberg to today: the ever present problems posed by metastatic tumors in the ovary: part I. Historical perspective, general principles, mucinous tumors including the krukenberg tumor.从库肯勃瘤到如今：卵巢转移性肿瘤带来的长期存在的问题：第一部分。历史视角、一般原则、黏液性肿瘤包括库肯勃瘤
Adv Anat Pathol. 2006 Sep;13(5):205-27. doi: 10.1097/01.pap.0000213038.85704.e4.
7
Molecular pathogenesis of pancreatic cancer.胰腺癌的分子发病机制
Best Pract Res Clin Gastroenterol. 2006 Apr;20(2):211-26. doi: 10.1016/j.bpg.2005.10.002.
8
Diagnostic challenge of secondary (metastatic) ovarian tumors simulating primary endometrioid and mucinous neoplasms.继发性（转移性）卵巢肿瘤模拟原发性子宫内膜样和黏液性肿瘤的诊断挑战。
Pathol Int. 2005 May;55(5):231-43. doi: 10.1111/j.1440-1827.2005.01819.x.
9
Identification of high-risk pancreatic cancer-prone families.高危胰腺癌倾向家族的识别。
Gastroenterol Clin North Am. 2004 Dec;33(4):907-18. doi: 10.1016/j.gtc.2004.07.011.
10
The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website.COSMIC（癌症体细胞突变目录）数据库及网站。
Br J Cancer. 2004 Jul 19;91(2):355-8. doi: 10.1038/sj.bjc.6601894.

A case of synchronous pancreatic ductal adenocarcinoma and ovarian mucinous cystic neoplasm: use of kras mutation molecular phenotyping to demonstrate independent primary origin.

作者信息

Lowery Maeve, Klimstra David, Hedvat Cyrus, Jarnagin William, Chi Dennis, O'Reilly Eileen M

出版信息

Gastrointest Cancer Res. 2012 Mar;5(2):67-70.

PMID:22690261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3369596/
Abstract
摘要