Riva Giulio, Pea Antonio, Pilati Camilla, Fiadone Giulia, Lawlor Rita Teresa, Scarpa Aldo, Luchini Claudio
Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona 37134, Italy.
Department of Surgery, University and Hospital trust of Verona, Verona 37134, Italy.
World J Gastrointest Oncol. 2018 Oct 15;10(10):317-327. doi: 10.4251/wjgo.v10.i10.317.
Pancreatic cancer is a lethal malignancy, whose precursor lesions are pancreatic intraepithelial neoplasm, intraductal papillary mucinous neoplasm, intraductal tubulopapillary neoplasm, and mucinous cystic neoplasm. To better understand the biology of pancreatic cancer, it is fundamental to know its precursors and to study the mechanisms of carcinogenesis. Each of these precursors displays peculiar histological features, as well as specific molecular alterations. Starting from such pre-invasive lesions, this review aims at summarizing the most important aspects of carcinogenesis of pancreatic cancer, with a specific focus on the recent advances and the future perspectives of the research on this lethal tumor type.
胰腺癌是一种致命的恶性肿瘤，其前驱病变包括胰腺上皮内瘤变、导管内乳头状黏液性肿瘤、导管内管状乳头状肿瘤和黏液性囊性肿瘤。为了更好地理解胰腺癌的生物学特性，了解其前驱病变并研究致癌机制至关重要。这些前驱病变中的每一种都具有独特的组织学特征以及特定的分子改变。从这些癌前病变出发，本综述旨在总结胰腺癌致癌作用的最重要方面，特别关注这种致命肿瘤类型研究的最新进展和未来前景。
