Sharova E V, Migalev A S, Kulikov M A, Voronov V G, Boldyreva G N, Zhavoronkova L A, Skoriatina I G, Piashina D V, Davydova N Iu, Pronin I N, Kornienko V N
Zh Vyssh Nerv Deiat Im I P Pavlova. 2012 Mar-Apr;62(2):143-56.
To gain a deeper insight into the relationship between the electrogenesis and oxygenation of the brain, fMRI and EEG reactions to identical functional loads (opening of the eyes and right- and left-hand fingering) were compared in 11 young right-handed healthy subjects with statistical techniques. Changes in power, frequency and coherent EEG parameters obtained by 18-channel monopolar recording were compared with values of + BOLD-fMRI response, calculated for 18 corresponding cortical areas on the basis of application of the "virtual cap" by the original algorithm. In reactive changes of both hemodynamic and bioelectrical parameters, sets of independent factors were identified, which were regarded on the basis of their topography as specific (localized in the cortical representation ofa relevant analyzer) and nonspecific (diffuse and similar under different functional loads). Specific component dominated in the fMRI response, whereas non-specific component was characteristic of the EEG reaction. The similar topography of reactive fMRI and EEG factors under normal conditions, confirmed by the correlation analysis, reflects the multilevel character of the systemic organization of the brain activity, visualized, in particular, in the sagittal projections of the individual fMRI images. Each of the reactive EEG factors included all of the EEG quantitative characteristics. EEG coherence, which dominated among other parameters (with a local increase in the cortical representation of a relevant analyzer and a diffuse decrease in the areas of the influence of the regulatory structures) displayed the highest correlation with hemodynamic responses of the brain.
为了更深入地了解大脑电活动与氧合作用之间的关系，运用统计技术对11名年轻右利手健康受试者在面对相同功能负荷（睁眼以及右手和左手手指运动）时的功能磁共振成像（fMRI）和脑电图（EEG）反应进行了比较。通过18通道单极记录获得的EEG功率、频率和相干参数的变化，与基于原始算法应用“虚拟帽”为18个相应皮质区域计算出的+BOLD-fMRI反应值进行了比较。在血液动力学和生物电参数的反应性变化中，识别出了几组独立因素，根据其拓扑结构，这些因素被视为特异性因素（局限于相关分析器的皮质代表区域）和非特异性因素（弥散且在不同功能负荷下相似）。特异性成分在fMRI反应中占主导，而非特异性成分是EEG反应的特征。正常条件下反应性fMRI和EEG因素的相似拓扑结构，经相关性分析证实，反映了大脑活动系统组织的多层次特征，尤其在个体fMRI图像的矢状投影中得以显现。每个反应性EEG因素都包含了所有的EEG定量特征。EEG相干性在其他参数中占主导（在相关分析器的皮质代表区域局部增加，在调节结构影响区域弥散性降低），与大脑的血液动力学反应显示出最高的相关性。
