Meshkov I O, Alekhina T A, Moreva T A, Markel' A L
Zh Vyssh Nerv Deiat Im I P Pavlova. 2012 Mar-Apr;62(2):233-42.
This work was performed in hypertensive ISIAH and normotensive WAG rat strains. The latter was used as a control group. The general evaluation of behavior of the ISIAH and WAG rats tested in the open field, in the light-dark test, in the sound stress test, and in the fatigue test showed that the motor and exploratory activity provoked by an unfamiliar environment was much higher in the ISIAH rats as compared to the control WAG strain. Spontaneous locomotor activity of the ISIAH rats in the home cage was significantly lower as compared to the control WAG strain. This finding suggests that the ISIAH rats are hyperreactive in an novel environment. It is concluded that the hypertensive ISIAH rats are significantly different from the control WAG rats not only in the arterial blood pressure level, but also in behavioral patterns.
本研究在高血压ISIAH大鼠品系和正常血压WAG大鼠品系中进行。后者用作对照组。对在旷场试验、明暗试验、声音应激试验和疲劳试验中测试的ISIAH和WAG大鼠的行为进行的总体评估表明,与对照WAG品系相比,ISIAH大鼠在陌生环境中引发的运动和探索活动要高得多。与对照WAG品系相比,ISIAH大鼠在其饲养笼中的自发运动活动明显更低。这一发现表明,ISIAH大鼠在新环境中反应过度。得出的结论是,高血压ISIAH大鼠不仅在动脉血压水平上,而且在行为模式上都与对照WAG大鼠有显著差异。