Grebeniuk A N, Bykov V N, Miasnikov V A, Zatsepin V V, Aksenova N V
Radiats Biol Radioecol. 2012 Mar-Apr;52(2):175-80.
The study was aimed at evaluating the radioprotective effectiveness of beta-estradiol following its prophylactic administration in conditions of acute irradiation. Evaluation of the radioprotective efficiency was performed by studying the 30-day survival rate, life expectancy, the structure of irradiated mice death, the bone marrow hematopoiesis using the method of exogenous colony formation. The prophylactic use of beta-estradiol at doses of 20 and 40 mg/kg 5 days before irradiation has been established to protect the exposed mice against radiation death induced by X-rays at doses LD50-90/30, thus increasing their survival rate by 17-58%, and to favor the reduced expression of post radiation disorders of bone marrow hematopoiesis.
该研究旨在评估在急性辐射条件下预防性给予β-雌二醇后的辐射防护效果。通过研究30天生存率、预期寿命、受辐照小鼠的死亡结构以及采用外源性集落形成法研究骨髓造血功能，对辐射防护效率进行了评估。已确定在照射前5天以20和40mg/kg的剂量预防性使用β-雌二醇，可保护受照小鼠免受LD50-90/30剂量的X射线诱导的辐射死亡，从而使它们的生存率提高17%-58%，并有利于降低骨髓造血功能辐射后紊乱的表达。
