[通过X射线照射小鼠的存活率和骨髓造血功能对染料木黄酮抗辐射效果进行实验评估]

[The experimental evaluation of antiradiation effectiveness of genistein by survival rates and bone marrow hemopoiesis of mice irradiated by X-rays].

作者信息

Grebeniuk A N, Basharin V A, Tarumov R A, Aksenova N V, Nazarov V B, Kovtun V Iu, Chekunov I E

出版信息

Radiats Biol Radioecol. 2013 Sep-Oct;53(5):468-74.

Abstract

The study was aimed at evaluating the radioprotective effectiveness of genistein administered at different times before or after acute irradiation. Evaluation ofradioprotective efficiency was performed by studying the 30-day survival rate, life expectancy, bone marrow hemapoiesis using the method of endogenous and exogenous colony formation. We have established that genistein at a dose of 200 mg/kg when administered 1 hour prior to irradiation has the highest radioprotective efficiency. In this case, genistein protects mice against death due to X-ray radiation at doses LD(50-90/30), increasing their survival rate by 30-44%, and reduces expression of post radiation disorders of bone marrow hematopoiesis.

摘要

该研究旨在评估金雀异黄素在急性辐射前或后不同时间给药的辐射防护效果。通过研究30天存活率、预期寿命以及采用内源性和外源性集落形成方法评估骨髓造血功能，来评价辐射防护效率。我们已经确定，在照射前1小时给予200mg/kg剂量的金雀异黄素具有最高的辐射防护效率。在这种情况下，金雀异黄素可保护小鼠免受LD(50 - 90/30)剂量的X射线辐射导致的死亡，使它们的存活率提高30 - 44%，并减少辐射后骨髓造血功能障碍的表达。