Zil'berter Iu I, Zil'berter T M
Usp Fiziol Nauk. 2012 Apr-Jun;43(2):37-54.
The review outlines current state of the thepretical, methodological and applies aspects of brain's energy homeostasis. Authors suggest reconsidering the exclusive role of glucose as an energy substrate (ES) at both neuronal and systemic levels discussing recent research data on qualitative composition of ES pool in the brain. The role of ES alternative to glucose, e.g., lactate and ketone bodies, is examined. The hypotheses of intracellular and astrocyte-neuron lactate shuttles are discussed along with the hypotheses of astrocyte-neuron shuttle of ketone bodies, the selfish brain theory and suppositions on homeostatic versus non-homeostatic ES supply chains. In conclusion, authors argue that exogenous native ES may be used for prevention and treatment of neurodegenerative diseases.
这篇综述概述了大脑能量稳态在理论、方法和应用方面的现状。作者建议重新审视葡萄糖作为能量底物（ES）在神经元和全身水平上的唯一作用，并讨论了有关大脑中ES池定性组成的最新研究数据。研究了替代葡萄糖的ES的作用，例如乳酸和酮体。讨论了细胞内和星形胶质细胞-神经元乳酸穿梭假说，以及酮体的星形胶质细胞-神经元穿梭假说、自私大脑理论和关于稳态与非稳态ES供应链的假设。总之，作者认为外源性天然ES可用于预防和治疗神经退行性疾病。
