Disciplina de Genética, Departamento de Morfologia e Genética, Escola Paulista de Medicina/Universidade Federal de São Paulo, Rua Botucatu 740, São Paulo, SP, Brazil.
Epigenomics. 2012 Jun;4(3):279-94. doi: 10.2217/epi.12.22.
Cancer is considered one of the major health issues worldwide, and gastric cancer accounted for 8% of total cases and 10% of total deaths in 2008. Gastric cancer is considered an age-related disease, and the total number of newly diagnosed cases has been increasing as a result of the higher life expectancy. Therefore, the basic mechanisms underlying gastric tumorigenesis is worth investigation. This review provides an overview of the epigenetic mechanisms, such as DNA methylation, histone modifications, chromatin remodeling complex and miRNA, involved in gastric cancer. As the studies in gastric cancer continue, the mapping of an epigenome code is not far for this disease. In conclusion, an epigenetic therapy might appear in the not too distant future.
癌症被认为是全球主要的健康问题之一，2008 年胃癌占总病例的 8%，总死亡人数的 10%。胃癌被认为是一种与年龄相关的疾病，由于预期寿命的提高，新诊断病例的总数一直在增加。因此，值得研究胃肿瘤发生的基本机制。本综述概述了胃癌中涉及的表观遗传机制，如 DNA 甲基化、组蛋白修饰、染色质重塑复合物和 miRNA。随着对胃癌的研究不断深入，为这种疾病绘制表观基因组图谱为期不远。总之，在不远的将来，表观遗传学疗法可能会出现。
