Woo Joo Hyun, Kim Sun Tae, Kang Il Gyu, Lee Ju Hyoung, Cha Heung Eog, Kim Dong Young
Department of Otorhinolaryngology-Head & Neck Surgery, Gil Hospital, Graduate School of Medicine, Gachon University, Incheon, Korea.
Acta Otolaryngol. 2012 Oct;132(10):1115-20. doi: 10.3109/00016489.2012.689859. Epub 2012 Jun 12.
The results of the study suggest that biofilms play a causative role in recurrent tonsillitis.
To analyze the association between tonsillar biofilms and recurrent tonsillitis.
The recurrent tonsillitis group comprised patients with a history of at least five episodes of tonsillitis per year over the previous 2 years. The control group comprised volunteers scheduled for laryngeal microsurgery with no history of tonsillitis over the previous 2 years. Between October 2009 and August 2010, specimens were obtained from 20 patients with recurrent tonsillitis and 20 volunteers (controls). Scanning electron microscopy (SEM) was used to confirm the presence of biofilms. Biofilms were graded at a magnification of ×500 by SEM and classified into five grades. The percentages of subjects affected and biofilm grades were compared between the recurrent tonsillitis and control groups.
The two groups were matched for age and sex. SEM revealed that biofilms were significantly more prevalent in the recurrent tonsillitis group than in the control group. Furthermore, the biofilms in the recurrent tonsillitis group were of significantly higher grade than those in the control group.
研究结果表明生物膜在复发性扁桃体炎中起致病作用。
分析扁桃体生物膜与复发性扁桃体炎之间的关联。
复发性扁桃体炎组包括在过去2年中每年至少有5次扁桃体炎发作史的患者。对照组包括计划进行喉显微手术且在过去2年中无扁桃体炎病史的志愿者。在2009年10月至2010年8月期间，从20例复发性扁桃体炎患者和20名志愿者（对照组）获取标本。使用扫描电子显微镜（SEM）确认生物膜的存在。通过SEM在×500放大倍数下对生物膜进行分级，并分为五个等级。比较复发性扁桃体炎组和对照组中受影响受试者的百分比和生物膜等级。
两组在年龄和性别方面相匹配。SEM显示，复发性扁桃体炎组中生物膜的发生率明显高于对照组。此外，复发性扁桃体炎组中的生物膜等级明显高于对照组。
