Department of Clinical Nutrition, Kyoritsu Women's University, Chiyoda-ku, Tokyo, Japan.
Clin Exp Hypertens. 2012;34(5):305-10. doi: 10.3109/10641963.2011.577484. Epub 2012 Jun 12.
We investigated the effects of sodium alginate oligosaccharides (alginate) on the development of spontaneous hypertension in rats. Spontaneous hypertensive rats were treated with alginate for 7 weeks. Systolic blood pressure (SBP) and cardiovascular and kidney damage were assessed. Systolic blood pressure increased in SHRs and this elevation was attenuated with alginate treatment. The heart weight tended to decline. Alginate did not change plasma cholesterol levels or urinary sodium excretions. The slightly higher urinary protein excretion in SHRs was not changed with the treatment; however, morphologic glomerular damage was significantly attenuated. Sodium alginate oligosaccharide attenuates spontaneous hypertension in SHRs, and may help prevent early-stage kidney injury.
我们研究了褐藻酸钠寡糖（褐藻酸盐）对自发性高血压大鼠发展的影响。用褐藻酸盐处理自发性高血压大鼠 7 周。评估收缩压（SBP）和心血管及肾脏损伤。SHR 组的收缩压升高，而褐藻酸盐处理可减轻这种升高。心脏重量有下降趋势。褐藻酸盐不改变血浆胆固醇水平或尿钠排泄。SHR 组的尿蛋白排泄略高，但治疗后无变化；然而，肾小球形态损伤明显减轻。褐藻酸钠寡糖可减轻自发性高血压大鼠的高血压，有助于预防早期肾脏损伤。
