Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea.
J Clin Periodontol. 2012 Aug;39(8):753-9. doi: 10.1111/j.1600-051X.2012.01908.x. Epub 2012 Jun 12.
The purpose of this study was to determine the effectiveness of adjunctive application of locally delivered minocycline ointment associated with flap surgery for the treatment of patients with chronic severe periodontitis.
Twenty patients with chronic severe periodontitis were treated in a split-mouth study to either adjunctive application of locally delivered minocycline ointment in association with flap surgery (FM) or flap surgery only (FO); additional minocycline application was performed at 3 months post operation. Clinical evaluation of the plaque index, probing depth (PD), bleeding on probing (BOP), gingival recession, and clinical attachment level (CAL) was conducted at baseline and at 3 and 6 months after treatment.
Clinical evaluations revealed that although both sites exhibited clinical improvement, there was a statistically significant reduction in PD (3.34 ± 0.03 mm) and BOP (78.01 ± 11.42%), and a significant gain of CAL (1.88 ± 0.21 mm) at the FM site compared with the FO site (reduction of PD and BOP: 2.62 ± 0.06 mm, 50.33 ± 15.01%, and gain of CAL: 1.55 ± 0.13 mm) at 6 months post operation (p < 0.05).
Adjunctive application of locally delivered minocycline may be beneficial to the surgical treatment protocol of chronic severe periodontitis.
本研究旨在确定局部应用米诺环素软膏联合翻瓣术治疗慢性重度牙周炎患者的疗效。
采用分口对照研究，对 20 例慢性重度牙周炎患者分别采用局部应用米诺环素软膏联合翻瓣术（FM）或单纯翻瓣术（FO）治疗；术后 3 个月行额外的米诺环素局部应用。分别于基线、治疗后 3 个月和 6 个月对菌斑指数、探诊深度（PD）、探诊出血（BOP）、牙龈退缩和临床附着水平（CAL）进行临床评估。
临床评估显示，尽管两个部位均有临床改善，但与 FO 组相比，FM 组 PD（3.34 ± 0.03 mm）和 BOP（78.01 ± 11.42%）显著降低，CAL 显著增加（1.88 ± 0.21 mm）（PD 和 BOP 的减少：2.62 ± 0.06 mm，50.33 ± 15.01%，CAL 的增加：1.55 ± 0.13 mm），差异有统计学意义（p < 0.05）。
局部应用米诺环素可辅助慢性重度牙周炎的手术治疗方案。
