Dipartimento di Chimica, Sapienza Università di Roma, Piazzale Aldo Moro, 5-00185-Roma, Italy.
Nat Prod Res. 2013 Mar;27(4-5):340-9. doi: 10.1080/14786419.2012.693924. Epub 2012 Jun 12.
Leaves of Olea europaea, cultivar Nocellara del Belice, were examined with respect to the medium-polar fraction, obtained by an ethyl acetate extraction of the whole extract. In the medium polar fraction, we isolated the two hydroxy-phenyl-ethyl alcohols (hydroxyl-tyrosol and tyrosol) that are the main component of olives. In addition, we isolated a flavonoidic compound, aromadendrine, a dihydroflavonol yet known but quite rare in nature. It is the first time that aromadendrine is isolated in O. europaea and we studied the aromadendrine biological activity. In particular, the ability of aromadendrine to reduce the inflammation induced in normal keratinocytes using an in vitro cell model was evaluated. The results of the present research indicate aromadendrine as a novel component in O. europaea with effective activity against skin inflammation.
我们研究了从整提物中用乙酸乙酯萃取得到的中等极性部位，发现了油橄榄（Olea europaea，品种名：Nocellara del Belice）的叶子中含有两种羟基苯乙醇（羟基酪醇和酪醇），这是橄榄的主要成分。此外，我们还分离出了一种黄酮类化合物，阿马多林，这是一种二氢黄酮醇，尽管在自然界中较为罕见，但目前已经有相关研究。这是首次在油橄榄中分离出阿马多林，我们还研究了其生物活性。具体来说，我们评估了阿马多林在体外细胞模型中对正常角质形成细胞诱导的炎症的抑制作用。本研究的结果表明，阿马多林是油橄榄中的一种新型成分，对皮肤炎症具有有效活性。
