番石榴原浆对高脂饮食诱导肥胖大鼠的有益降脂作用。

Beneficial lipid-lowering effects of pink guava puree in high fat diet induced-obese rats.

作者信息

Norazmir M N, Ayub M Y

机构信息

School of Chemical Sciences and Food Technology, Faculty of Science and Technology Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.

出版信息

Malays J Nutr. 2010 Apr;16(1):171-85. Epub 2010 Apr 15.

PMID:22691864

Abstract

A study was carried out to determine the anti-obesity effects of pink guava (Psidium guajava) puree in high fat diet (HFD) induced-obese rats. Thirty male Sprague-Dawley rats were divided into 5 groups: control negative (CN), fed normal rat pellet; control positive (CP), low, medium and high dosage group (LDG, MDG, HDG) were fed HFD, respectively. CN and CP groups were given distilled water; meanwhile treated groups were given the aqueous puree dissolved in distilled water administered orally for six weeks. The results obtained showed that pink guava puree significantly decreased the body weight and systolic blood pressure of HFD induced-obese rats as compared to control. Blood glucose values for treated groups (4.3-4.9 mmol/L) were significantly lower as compared to CN and CP (5.7 and 5.8 mmol/L) respectively. HDG showed a significant reduction in 34.47% total cholesterol (TC) levels followed by MDG (23.30%) and LDG (22.33%). Triglycerides (TG) levels for all treated groups especially HDG (43.59%) showed significant difference as compared to control. High density lipoprotein-cholesterol (HDL-C) levels showed an increase in the treated group as compared to control. Low density lipoprotein-cholesterol (LDL-C) levels significantly decreased in HDG (69.70%), MDG (39.40%) and LDG (37.12%) as compared to control. Kidney function tests showed significant changes in urea concentrations in treated groups as compared to control. Liver function tests showed significant differences in globulin, A:G ratio, alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and CK-Nac in treated groups as compared to control. Specific enzyme activities of glutathione peroxidase (GPx) was significantly higher in LDG (2787.50±266.36 U/L), MDG (2819.50±262.04 U/L) and HDG (2897.33±674.97 U/L) respectively, as compared to CN (2184.50±816.59 U/L) and CP (2610.17±61.63 U/L). Significant differences were also seen in superoxidase dismutase (SOD) activities in treated groups as compared to control. In conclusion, this study found that pink guava puree had anti-obesity properties and high enzyme activities.

摘要

开展了一项研究，以确定番石榴泥对高脂饮食（HFD）诱导肥胖大鼠的抗肥胖作用。30只雄性Sprague-Dawley大鼠分为5组：阴性对照组（CN），喂食正常大鼠颗粒饲料；阳性对照组（CP），低、中、高剂量组（LDG、MDG、HDG）分别喂食高脂饮食。CN组和CP组给予蒸馏水；同时，治疗组给予溶于蒸馏水的番石榴泥水溶液，口服6周。结果表明，与对照组相比，番石榴泥显著降低了高脂饮食诱导肥胖大鼠的体重和收缩压。治疗组的血糖值（4.3 - 4.9 mmol/L）分别显著低于CN组和CP组（5.7和5.8 mmol/L）。HDG组总胆固醇（TC）水平显著降低34.47%，其次是MDG组（23.30%）和LDG组（22.33%）。与对照组相比，所有治疗组的甘油三酯（TG）水平，尤其是HDG组（43.59%），均显示出显著差异。与对照组相比，治疗组的高密度脂蛋白胆固醇（HDL-C）水平有所升高。与对照组相比，HDG组（69.70%）、MDG组（39.40%）和LDG组（37.12%）的低密度脂蛋白胆固醇（LDL-C）水平显著降低。肾功能测试表明，与对照组相比，治疗组的尿素浓度有显著变化。肝功能测试表明，与对照组相比，治疗组的球蛋白、A:G比值、丙氨酸转氨酶（ALT）、乳酸脱氢酶（LDH）和肌酸激酶-Nac有显著差异。与CN组（2184.50±816.59 U/L）和CP组（2610.17±61.63 U/L）相比，LDG组（2787.50±266.36 U/L）、MDG组（2819.50±262.04 U/L）和HDG组（2897.33±674.97 U/L）的谷胱甘肽过氧化物酶（GPx）特异性酶活性分别显著更高。与对照组相比，治疗组的超氧化物歧化酶（SOD）活性也有显著差异。总之，本研究发现番石榴泥具有抗肥胖特性和高酶活性。