• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

急性和慢性 HIV 感染患者的传播性抗逆转录病毒药物耐药率不同。

Prevalence of transmitted antiretroviral drug resistance differs between acutely and chronically HIV-infected patients.

机构信息

Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA.

出版信息

J Acquir Immune Defic Syndr. 2012 Oct 1;61(2):258-62. doi: 10.1097/QAI.0b013e3182618f05.

DOI:10.1097/QAI.0b013e3182618f05
PMID:22692092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3458150/
Abstract

The associations of acute HIV infection (AHI) and other predictors with transmitted drug resistance (TDR) prevalence were assessed in a cohort of HIV-infected, antiretroviral-naïve patients. AHI was defined as being seronegative with detectable HIV RNA. Binomial regression was used to estimate prevalence ratios and 95% confidence intervals for associations with TDR. Among 43 AHI patients, TDR prevalence was 20.9%, whereas prevalence was 8.6% among 677 chronically infected patients. AHI was associated with 1.9 times the prevalence of TDR (95% confidence intervals: 1.0 to 3.6) in multivariable analysis. AHI patients may represent a vanguard group that portends increasing TDR in the future.

摘要

在一组未经抗逆转录病毒治疗的 HIV 感染、抗逆转录病毒治疗初治患者中，评估了急性 HIV 感染 (AHI) 和其他预测因素与传播性耐药 (TDR) 流行率的相关性。AHI 的定义为 HIV RNA 可检测但血清阴性。采用二项回归估计与 TDR 相关的关联的患病率比和 95%置信区间。在 43 名 AHI 患者中，TDR 患病率为 20.9%，而在 677 名慢性感染患者中，患病率为 8.6%。多变量分析显示，AHI 与 TDR 的患病率增加 1.9 倍（95%置信区间：1.0 至 3.6）相关。AHI 患者可能代表一个先锋群体，预示着未来 TDR 的增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/156e/3458150/e86b2a327297/nihms391679f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/156e/3458150/e86b2a327297/nihms391679f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/156e/3458150/e86b2a327297/nihms391679f1.jpg

相似文献

1
Prevalence of transmitted antiretroviral drug resistance differs between acutely and chronically HIV-infected patients.急性和慢性 HIV 感染患者的传播性抗逆转录病毒药物耐药率不同。
J Acquir Immune Defic Syndr. 2012 Oct 1;61(2):258-62. doi: 10.1097/QAI.0b013e3182618f05.
2
Transmitted antiretroviral drug resistance in the men who have sex with men HIV patient cohort, Beijing, China, 2008-2011.2008 - 2011年中国北京男男性行为艾滋病毒患者队列中的传播性抗逆转录病毒药物耐药性
Viral Immunol. 2014 Oct;27(8):392-7. doi: 10.1089/vim.2014.0025. Epub 2014 Aug 1.
3
Opportunities for sexual transmission of antiretroviral drug resistance among HIV-infected patients in care.接受治疗的HIV感染患者中抗逆转录病毒药物耐药性的性传播机会。
AIDS. 2013 Nov 28;27(18):2873-81. doi: 10.1097/01.aids.0000433240.78739.30.
4
Prevalence of transmitted HIV drug resistance among newly diagnosed antiretroviral therapy-naive pregnant women in Lilongwe and Blantyre, Malawi.马拉维利隆圭和布兰太尔新诊断为抗逆转录病毒治疗初治的孕妇中传播的 HIV 耐药性流行情况。
Clin Infect Dis. 2012 May;54 Suppl 4(Suppl 4):S324-7. doi: 10.1093/cid/cir993.
5
Surveillance of HIV-1 pol transmitted drug resistance in acutely and recently infected antiretroviral drug-naïve persons in rural western Kenya.肯尼亚西部农村地区急性和近期感染且未接受过抗逆转录病毒治疗的人群中HIV-1 pol传播耐药性的监测
PLoS One. 2017 Feb 8;12(2):e0171124. doi: 10.1371/journal.pone.0171124. eCollection 2017.
6
Surveillance of transmitted HIV drug resistance in antiretroviral-naive patients aged less than 25 years, in Bangkok, Thailand.泰国曼谷25岁以下未接受过抗逆转录病毒治疗患者中传播的HIV耐药性监测。
J Int Assoc Provid AIDS Care. 2014 Jan-Feb;13(1):12-4. doi: 10.1177/2325957413488200. Epub 2013 May 24.
7
Analysis of transmitted drug resistance in Spain in the years 2007-2010 documents a decline in mutations to the non-nucleoside drug class.分析 2007-2010 年西班牙的传播耐药性，发现非核苷类药物类别的突变呈下降趋势。
Clin Microbiol Infect. 2012 Nov;18(11):E485-90. doi: 10.1111/1469-0691.12011. Epub 2012 Sep 27.
8
Transmission of HIV-1 drug-resistant variants: prevalence and effect on treatment outcome.HIV-1 耐药变异体的传播：流行率及其对治疗效果的影响。
Clin Infect Dis. 2010 Feb 15;50(4):566-73. doi: 10.1086/650001.
9
Assessing the Paradox Between Transmitted and Acquired HIV Type 1 Drug Resistance Mutations in the Swiss HIV Cohort Study From 1998 to 2012.在1998年至2012年瑞士HIV队列研究中评估1型人类免疫缺陷病毒传播与获得性耐药突变之间的矛盾
J Infect Dis. 2015 Jul 1;212(1):28-38. doi: 10.1093/infdis/jiv012. Epub 2015 Jan 9.
10
Community HIV-1 drug resistance is associated with transmitted drug resistance.社区获得性HIV-1耐药性与传播性耐药性相关。
HIV Med. 2014 Jul;15(6):339-46. doi: 10.1111/hiv.12122. Epub 2014 Jan 12.

引用本文的文献

1
Characterization of Human Immunodeficiency Virus-1 Transmission Clusters and Transmitted Drug-Resistant Mutations in Croatia from 2019 to 2022.2019 年至 2022 年克罗地亚人类免疫缺陷病毒-1 传播簇和传播耐药突变的特征。
Viruses. 2023 Dec 11;15(12):2408. doi: 10.3390/v15122408.
2
Factors Associated With Newly HIV Infection and Transmitted Drug Resistance Among Men Who Have Sex With Men in Harbin, P.R. China.中国哈尔滨男男性行为人群中与新发 HIV 感染和传播耐药性相关的因素。
Front Public Health. 2022 Jun 2;10:860171. doi: 10.3389/fpubh.2022.860171. eCollection 2022.
3
Transmitted Drug Resistance in Antiretroviral Therapy-Naive Persons With Acute/Early/Primary HIV Infection: A Systematic Review and Meta-Analysis.初治急性/早期/原发性HIV感染患者抗逆转录病毒治疗中的传播耐药性：一项系统评价和荟萃分析
Front Pharmacol. 2021 Nov 24;12:718763. doi: 10.3389/fphar.2021.718763. eCollection 2021.
4
Transmitted HIV-1 drug resistance in a large international cohort using next-generation sequencing: results from the Strategic Timing of Antiretroviral Treatment (START) study.利用下一代测序技术在大型国际队列中检测到的传播性 HIV-1 耐药性：来自抗逆转录病毒治疗时机选择（START）研究的结果。
HIV Med. 2021 May;22(5):360-371. doi: 10.1111/hiv.13038. Epub 2020 Dec 25.
5
Pretreatment and Acquired Antiretroviral Drug Resistance Among Persons Living With HIV in Four African Countries.四个非洲国家 HIV 感染者的治疗前和获得性抗逆转录病毒药物耐药情况。
Clin Infect Dis. 2021 Oct 5;73(7):e2311-e2322. doi: 10.1093/cid/ciaa1161.
6
Efficacy, pharmacokinetics and neurocognitive performance of dual, NRTI-sparing antiretroviral therapy in acute HIV-infection.在急性 HIV 感染中，双重、非核苷类逆转录酶抑制剂节省型抗逆转录病毒疗法的疗效、药代动力学和神经认知表现。
AIDS. 2020 Nov 1;34(13):1923-1931. doi: 10.1097/QAD.0000000000002652.
7
Transmitted, pre-treatment and acquired antiretroviral drug resistance among men who have sex with men and transgender women living with HIV in Nigeria.尼日利亚男同性恋者和感染艾滋病毒的变性女性中传播的、治疗前和获得性抗逆转录病毒药物耐药性情况。
Antivir Ther. 2019;24(8):595-601. doi: 10.3851/IMP3342.
8
Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia.分析克罗地亚的 HIV-1 多样性、原发性耐药性和传播网络。
Sci Rep. 2019 Nov 21;9(1):17307. doi: 10.1038/s41598-019-53520-8.
9
Bridging the gap between HIV epidemiology and antiretroviral resistance evolution: Modelling the spread of resistance in South Africa.弥合 HIV 流行病学与抗逆转录病毒耐药性演变之间的差距：南非耐药性传播模型。
PLoS Comput Biol. 2019 Jun 24;15(6):e1007083. doi: 10.1371/journal.pcbi.1007083. eCollection 2019 Jun.
10
HIV-1C proviral DNA for detection of drug resistance mutations.HIV-1C 前病毒 DNA 用于检测耐药突变。
PLoS One. 2018 Oct 4;13(10):e0205119. doi: 10.1371/journal.pone.0205119. eCollection 2018.

本文引用的文献

1
Transmitted drug-resistant HIV type 1 remains prevalent and impacts virologic outcomes despite genotype-guided antiretroviral therapy.尽管有基因型指导的抗逆转录病毒疗法，但传播的耐药性1型艾滋病毒仍然普遍存在，并影响病毒学结果。
AIDS Res Hum Retroviruses. 2012 Mar;28(3):259-64. doi: 10.1089/aid.2011.0022. Epub 2011 Aug 30.
2
Transmitted drug resistance in the CFAR network of integrated clinical systems cohort: prevalence and effects on pre-therapy CD4 and viral load.CFAR 网络整合临床系统队列中的传播性耐药：流行率及其对治疗前 CD4 和病毒载量的影响。
PLoS One. 2011;6(6):e21189. doi: 10.1371/journal.pone.0021189. Epub 2011 Jun 20.
3
Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: a systematic review and pooled analysis.低频 HIV-1 耐药突变与 NNRTI 为基础的抗逆转录病毒治疗失败风险：系统评价和汇总分析。
JAMA. 2011 Apr 6;305(13):1327-35. doi: 10.1001/jama.2011.375.
4
Differential persistence of transmitted HIV-1 drug resistance mutation classes.传播的 HIV-1 耐药突变类别的差异持久性。
J Infect Dis. 2011 Apr 15;203(8):1174-81. doi: 10.1093/infdis/jiq167.
5
Transmitted resistance to HIV integrase strand-transfer inhibitors: right on schedule.对HIV整合酶链转移抑制剂的传播性耐药：如期出现。
Antivir Ther. 2011;16(2):137-40. doi: 10.3851/IMP1750.
6
Effect of transmitted drug resistance on virological and immunological response to initial combination antiretroviral therapy for HIV (EuroCoord-CHAIN joint project): a European multicohort study.传播耐药性对初始联合抗逆转录病毒治疗 HIV 的病毒学和免疫学反应的影响（EuroCoord-CHAIN 联合项目）：一项欧洲多队列研究。
Lancet Infect Dis. 2011 May;11(5):363-71. doi: 10.1016/S1473-3099(11)70032-9. Epub 2011 Feb 25.
7
Transmitted drug resistance in persons with acute/early HIV-1 in San Francisco, 2002-2009.2002-2009 年旧金山急性/早期 HIV-1 感染者的传播耐药性。
PLoS One. 2010 Dec 10;5(12):e15510. doi: 10.1371/journal.pone.0015510.
8
Prevalence of transmitted drug resistance and impact of transmitted resistance on treatment success in the German HIV-1 Seroconverter Cohort.德国 HIV-1 血清转换队列中传播耐药性的流行情况及其对治疗成功的影响。
PLoS One. 2010 Oct 7;5(10):e12718. doi: 10.1371/journal.pone.0012718.
9
Late presentation for human immunodeficiency virus care in the United States and Canada.美国和加拿大的人类免疫缺陷病毒护理晚期就诊。
Clin Infect Dis. 2010 Jun 1;50(11):1512-20. doi: 10.1086/652650.
10
Prevalence of transmitted drug resistance associated mutations and HIV-1 subtypes in new HIV-1 diagnoses, U.S.-2006.2006 年美国新诊断 HIV-1 感染者中传播相关耐药突变与 HIV-1 亚型的流行情况
AIDS. 2010 May 15;24(8):1203-12. doi: 10.1097/QAD.0b013e3283388742.