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中国哈尔滨男男性行为人群中与新发 HIV 感染和传播耐药性相关的因素。

Factors Associated With Newly HIV Infection and Transmitted Drug Resistance Among Men Who Have Sex With Men in Harbin, P.R. China.

机构信息

Department of Epidemiology, College of Public Health, Harbin Medical University, Harbin, China.

Heilongjiang Provincial Center for Disease Control and Prevention, Harbin, China.

出版信息

Front Public Health. 2022 Jun 2;10:860171. doi: 10.3389/fpubh.2022.860171. eCollection 2022.

Abstract

BACKGROUND

This study aimed to evaluate HIV incidence, factors associated with HIV incidence and transmitted drug resistance (TDR) among newly infected men who have sex with men (MSM) in Harbin, P.R. China.

METHODS

A cohort study was conducted among MSM in Harbin during 2013 and 2018, with a follow-up frequency of every 6 months. Blood samples from MSM were tested for HIV antibodies, RNA was extracted from plasma, and the gene was sequenced, and genotypic drug-resistance analyses were performed.

RESULTS

From 2013 to 2018, the overall rate of HIV incidence was 3.55/100 PY. Syphilis infection, unprotected sex with men in the past 6 months, and unawareness of HIV/AIDS knowledge were risk factors for HIV seroconversion. The distribution of HIV genotypes was as follows: CRF01_AE, 57.1%; CRF07_BC, 28.5%; CRF55_01B, 2.0%; B, 8.2%. The prevalence of transmitted drug resistance was 4.08%.

CONCLUSION

HIV incidence in MSM in Harbin is moderately high, and transmitted drug resistance exists in the population.

摘要

背景

本研究旨在评估中国哈尔滨新感染男男性行为者(MSM)中的 HIV 发病率、与 HIV 发病率相关的因素以及传播性耐药(TDR)。

方法

2013 年至 2018 年期间在哈尔滨对 MSM 进行了队列研究,随访频率为每 6 个月一次。对 MSM 的血液样本进行 HIV 抗体检测,从血浆中提取 RNA,并对 基因进行测序和基因型耐药性分析。

结果

2013 年至 2018 年期间,HIV 总发病率为 3.55/100PY。梅毒感染、过去 6 个月与男性无保护性行为以及对 HIV/AIDS 知识的不了解是 HIV 血清转换的危险因素。HIV 基因型分布如下:CRF01_AE,57.1%;CRF07_BC,28.5%;CRF55_01B,2.0%;B,8.2%。传播性耐药的流行率为 4.08%。

结论

哈尔滨 MSM 的 HIV 发病率较高,且人群中存在传播性耐药。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee00/9201057/17beec2d45e1/fpubh-10-860171-g0001.jpg

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