The Department of Pathology & Laboratory Medicine and the Abramson Family Cancer Research Institute at the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Semin Immunol. 2010 Oct;22(5):261-9. doi: 10.1016/j.smim.2010.04.015. Epub 2010 Jul 13.
Notch signaling plays multiple roles in T cell development. Following thymic entry, Notch signals are required to specify the T cell fate from a multipotent hematopoietic progenitor. At subsequent steps in early T cell development, Notch provides important differentiation, survival, proliferation and metabolic signals. This review focuses on the multiple functions of Notch in early T cell development, from T cell specification in the thymus through beta selection.
Notch 信号通路在 T 细胞发育中发挥多种作用。在进入胸腺后，Notch 信号对于从多能造血祖细胞中特异性指定 T 细胞命运是必需的。在早期 T 细胞发育的后续步骤中，Notch 提供了重要的分化、存活、增殖和代谢信号。本综述重点介绍了 Notch 在早期 T 细胞发育中的多种功能，从胸腺中的 T 细胞特异性到β选择。
