Italian Inter-University Centre of Electromagnetic Fieldsand Bio-Systems, Italian National Agency for New Technologies, Energy,and Sustainable Economic Development, Rome, Italy.
IEEE Trans Biomed Eng. 2012 Aug;59(8):2302-11. doi: 10.1109/TBME.2012.2203133. Epub 2012 Jun 6.
Microdosimetric models for biological cells have assumed increasing significance in the development of nanosecond pulsed electric field technology for medical applications. In this paper, novel passive element circuits, able to take into account the dielectric dispersion of the cell, are provided. The circuital analyses are performed on a set of input pulses classified in accordance with the current literature. Accurate data in terms of transmembrane potential are obtained in both time and frequency domains for different cell models. In addition, a sensitivity study of the transfer function for the cell geometrical and dielectric parameters has been carried out. This analysis offers a new, simple, and efficient tool to characterize the nsPEFs' action at the cellular level.
微剂量模型在生物细胞中的应用越来越重要，特别是在纳秒脉冲电场技术的医学应用方面。本文提供了能够考虑细胞介电色散的新型无源元件电路。根据当前文献对一组输入脉冲进行了电路分析。对于不同的细胞模型，在时域和频域都获得了跨膜电位的精确数据。此外，还对细胞几何和介电参数的传递函数进行了灵敏度研究。该分析为在细胞水平上表征纳秒 PEF 的作用提供了一种新的、简单和有效的工具。
