Department of Otorhinolaryngology Head and Neck Surgery, Xuanwu Hospital of Capital University of Medical Science, Beijing 100053, China.
Anat Rec (Hoboken). 2012 Aug;295(8):1252-9. doi: 10.1002/ar.22507. Epub 2012 Jun 13.
This study aimed to investigate the incidence of direct invasion and metastasis of nasopharyngeal carcinoma (NPC) at different anatomic sites in the skull base using magnetic resonance imaging (MRI). MRI data from 101 NPC patients with skull base invasion were collected and we analyzed the incidence and anatomic sites of invasion of NPC in the skull base. Of the 101 NPC patients, 84 had direct invasion at the skull base (83.2%), and 17 had skull base metastasis (16.8%). Affected sites with direct invasion in the skull base included sphenoid sinus and sella base, cavernous sinus, internal carotid canal, and clivus blumenbachii. Skull base metastasis sites included the internal carotid canal and jugular foramen area. Because of early lymphatic metastasis of NPC to the skull base, MRI examination can be helpful in increasing the accuracy of diagnostic imaging for skull base invasion of NPC and selecting appropriate target sites, radiotherapy techniques, and operative approaches.
本研究旨在利用磁共振成像（MRI）探讨鼻咽癌（NPC）在颅底不同解剖部位的直接侵犯和转移的发生率。收集了 101 例颅底侵犯的 NPC 患者的 MRI 数据，并分析了 NPC 在颅底的侵犯和转移的解剖部位。在 101 例 NPC 患者中，84 例有颅底直接侵犯（83.2%），17 例有颅底转移（16.8%）。颅底直接侵犯的受累部位包括蝶窦和鞍底、海绵窦、颈内动脉管和斜坡 Blumenbachii。颅底转移部位包括颈内动脉管和颈静脉孔区。由于 NPC 对颅底的早期淋巴转移，MRI 检查有助于提高 NPC 颅底侵犯的诊断成像准确性，并选择合适的靶区、放疗技术和手术方法。
