药物超敏反应伴嗜酸性粒细胞增多和系统症状综合征：一例病例报告及文献综述
DRESS syndrome: a case report and literature review.
作者信息
Cardoso Cláudia Sofia, Vieira Ana Margarida, Oliveira Ana Paula
机构信息
Department of Gastroenterology, Centro Hospitalar de Setúbal, Setúbal, Portugal.
出版信息
BMJ Case Rep. 2011 Jun 3;2011:bcr0220113898. doi: 10.1136/bcr.02.2011.3898.
Abstract
DRESS syndrome (drug rash, eosinophilia and systemic symptoms) is an idiosyncratic drug reaction characterised by rash, fever, lymphadenopathy and internal organ involvement. The authors report a case of this syndrome presenting with fever, generalised pruritus, macular rash and cholestatic hepatitis during allopurinol treatment. This case resolved with drug withdrawal, but the death rate in the setting of hepatic failure can reach 10%. Rapid diagnosis is crucial as prompt withdrawal of the offending drug is the key of the treatment, while the potential role of corticosteroids remains controversial.
摘要
药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS综合征）是一种特异质性药物反应，其特征为皮疹、发热、淋巴结病和内脏器官受累。作者报告了1例在使用别嘌醇治疗期间出现发热、全身性瘙痒、斑丘疹和胆汁淤积性肝炎的该综合征病例。该病例经停药后痊愈，但肝衰竭情况下的死亡率可达10%。快速诊断至关重要，因为迅速停用致病药物是治疗的关键，而皮质类固醇的潜在作用仍存在争议。
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本文引用的文献
1
Drug-induced hypersensitivity syndrome: clinical and biologic disease patterns in 24 patients.药物性超敏反应综合征：24例患者的临床和生物学疾病模式
Medicine (Baltimore). 2009 May;88(3):131-140. doi: 10.1097/MD.0b013e3181a4d1a1.
2
Allopurinol-induced recurrent DRESS syndrome: pathophysiology and treatment.别嘌醇诱发的复发性药物超敏反应综合征：病理生理学与治疗
Ren Fail. 2008;30(3):327-9. doi: 10.1080/08860220701861045.
3
Clinical heterogeneity of drug hypersensitivity.药物超敏反应的临床异质性。
Toxicology. 2005 Apr 15;209(2):123-9. doi: 10.1016/j.tox.2004.12.022.
4
DRESS syndrome in a patient on sulfasalazine for rheumatoid arthritis.一名类风湿关节炎患者在服用柳氮磺胺吡啶后出现药物超敏反应伴嗜酸性粒细胞增多和系统症状（DRESS）综合征。
Joint Bone Spine. 2005 Jan;72(1):82-5. doi: 10.1016/j.jbspin.2004.06.002.
5
The lymphocyte transformation test in the diagnosis of drug hypersensitivity.淋巴细胞转化试验在药物过敏诊断中的应用
Allergy. 2004 Aug;59(8):809-20. doi: 10.1111/j.1398-9995.2004.00547.x.
6
[Drug hypersensitivity syndrome: DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms)].
Ann Dermatol Venereol. 2004 Mar;131(3):293-7. doi: 10.1016/s0151-9638(04)93600-9.
7
Lymphadenopathy induced by anticonvulsant drugs and mimicking clinically pathologically malignant lymphomas.抗惊厥药物所致淋巴结病，临床病理表现酷似恶性淋巴瘤。
Cancer. 1959 Jan-Feb;12(1):164-82. doi: 10.1002/1097-0142(195901/02)12:1<164::aid-cncr2820120122>3.0.co;2-y.
8
Down-regulated IL-5 receptor expression on peripheral blood eosinophils from budesonide-treated children with asthma.布地奈德治疗的哮喘儿童外周血嗜酸性粒细胞上白细胞介素-5受体表达下调。
Allergy. 2002 Apr;57(4):323-8. doi: 10.1034/j.1398-9995.2002.1o3482.x.
9
The drug hypersensitivity syndrome: what is the pathogenesis?药物超敏反应综合征：发病机制是什么？
Arch Dermatol. 2001 Mar;137(3):357-64.
10
Treatment of severe drug eruptions.严重药物疹的治疗。
J Dermatol. 1999 Nov;26(11):718-22. doi: 10.1111/j.1346-8138.1999.tb02082.x.
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