Sahukar Srushti, Chandrappa Byranahalli Vijay
Internal Medicine, Nanjappa Hospital, Davangere, IND.
Anesthesiology and Critical Care, Nanjappa Hospital, Davangere, IND.
Cureus. 2024 Jul 22;16(7):e65128. doi: 10.7759/cureus.65128. eCollection 2024 Jul.
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome usually presents two to six weeks after treatment with a drug implicated in this disorder. However, in some cases, it can present more than eight weeks after the initiation of an implicated medication. This is a type 4 drug hypersensitivity reaction in which any internal organ may be involved. While the liver is commonly involved, cardiac involvement is not unheard of. Comorbidities and multiorgan involvement may obscure the diagnosis, and Registry of Severe Cutaneous Adverse Reactions (RegiSCAR) criteria are a useful diagnostic aid. It is best treated by withdrawing the offending agent and administering systemic steroids. Oxidative stress is high in DRESS syndrome. Hepatoprotection is a priority in all patients and yields a better prognosis.
药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）综合征通常在使用与此疾病相关的药物治疗后两到六周出现。然而，在某些情况下，它可能在开始使用相关药物八周后出现。这是一种4型药物超敏反应，任何内脏器官都可能受累。虽然肝脏通常受累，但心脏受累也并非罕见。合并症和多器官受累可能会掩盖诊断，严重皮肤不良反应登记处（RegiSCAR）标准是一种有用的诊断辅助工具。最好的治疗方法是停用致病药物并给予全身性类固醇。DRESS综合征中氧化应激水平较高。对所有患者来说，肝脏保护是首要任务，且预后较好。
