Kaufmann D, Pichler W, Beer J H
Department of Internal Medicine, University Hospital, Bern, Switzerland.
Arch Intern Med. 1994 Sep 12;154(17):1983-4.
Minocycline is a tetracycline agent frequently used for acne therapy. It has a few rare but severe side effects that are not widely known but should be recognized early as drug related. These include acute hepatitis and liver failure; a Löffler-like syndrome with pulmonary infiltrates, wheezing, fever, and eosinophilia; skin eruptions, eosinophilic cellulitis, and pustular folliculitis with eosinophilia; and a lupuslike syndrome. Side effects that are better known and recognized include photosensitization, skin exanthema with pruritus, and pseudotumor cerebri.
米诺环素是一种常用于痤疮治疗的四环素类药物。它有一些罕见但严重的副作用，这些副作用并不广为人知，但应尽早识别为与药物相关。这些副作用包括急性肝炎和肝衰竭；伴有肺部浸润、喘息、发热和嗜酸性粒细胞增多的类吕弗勒综合征；皮肤疹、嗜酸性粒细胞性蜂窝织炎和伴有嗜酸性粒细胞增多的脓疱性毛囊炎；以及类狼疮综合征。更常见和为人所知的副作用包括光敏反应、伴有瘙痒的皮肤疹和假脑瘤。
