Khan Arshad Bashir, Al Suhaibani Youssuf, Al Mohaimed Khaled, Morris David L
Indian J Surg Oncol. 2010 Sep;1(3):270-3. doi: 10.1007/s13193-010-0036-4. Epub 2010 Dec 23.
Pseudomyxoma peritonei following dissemination of appendicealmucinous neoplasms is slowly progressive but inevitably a lethal condition. It is locally invasive and does not lead to lymph node or distant metastasis making it amenable for more radical procedures. We present a case of pseudomyxoma peritonei treated by Cytoreductive surgery(CRS)and heated intraperitoneal chemotherapy(HIPEC) with Mitomycin C (12.5mg/m2 ) at 41.50 C. This was followed by five cycles of early postoperative intraperitoneal chemotherapy (EPIC) with 5FU (650 mg/m2) over 5 days. Patient underwent standard Peritonectomy procedure combined with resection of gallbladder, Spleen, subtotal colectomy and resection of part of small bowel. Blood loss during theprocedure was 4000ml. Histopathology revealed Pseudomyxoma peritonei (hybrid type). The patient recuperated well and was discharged and now is living a productive life. Peritonectomy with perioperative intraperitoneal chemotherapy is the current standard of treatment for appendiceal tumors with peritoneal dissemination which offers a hope of disease free long survival in such patients.
阑尾黏液性肿瘤播散后引起的腹膜假黏液瘤进展缓慢，但最终会致命。它具有局部侵袭性，不会导致淋巴结转移或远处转移，因此适合采用更彻底的手术治疗。我们报告一例腹膜假黏液瘤患者，接受了细胞减灭术（CRS）及术中41.50℃热灌注化疗（HIPEC），使用丝裂霉素C（12.5mg/m²）。术后早期又进行了5个周期的腹腔内化疗（EPIC），使用5-氟尿嘧啶（5FU，650mg/m²），持续5天。患者接受了标准的腹膜切除术，同时切除了胆囊、脾脏、次全结肠切除术及部分小肠切除术。手术中失血4000ml。组织病理学检查显示为腹膜假黏液瘤（混合型）。患者恢复良好并出院，现在过着充实的生活。对于阑尾肿瘤伴腹膜播散患者，围手术期腹腔内化疗的腹膜切除术是目前的标准治疗方法，有望使此类患者长期无病生存。
