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Immunoelectron microscopical localization of the catalytic subunit of cAMP-dependent protein kinases in brain microtubules and neurofilaments.

作者信息

Trinczek B, Schwoch G

机构信息

Zentrum Innere Medizin, Universität Göttingen, Germany.

出版信息

FEBS Lett. 1990 Dec 17;277(1-2):167-70. doi: 10.1016/0014-5793(90)80835-7.

DOI:10.1016/0014-5793(90)80835-7
PMID:2269349
Abstract

The catalytic subunit of cAMP-dependent protein kinases was localized in microtubules and neurofilaments by immunogold electron microscopy. In microtubules, the label was similarly distributed as an immunolabel for the microtubule associated protein MAP 2. The neurofilaments showed no reaction with the MAP 2-antiserum. Our results support the suggestion of an in vivo role of cAMP-dependent protein kinases in the regulation of microtubules. In addition, this is the first demonstration that cAMP-dependent protein kinase is associated with neurofilaments.

摘要

相似文献

1
Immunoelectron microscopical localization of the catalytic subunit of cAMP-dependent protein kinases in brain microtubules and neurofilaments.
FEBS Lett. 1990 Dec 17;277(1-2):167-70. doi: 10.1016/0014-5793(90)80835-7.
2
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引用本文的文献

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Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356.Tau蛋白在其微管结合结构域内的丝氨酸262和丝氨酸356位点被环磷酸腺苷依赖性蛋白激酶以及钙/钙调蛋白依赖性蛋白激酶II磷酸化。
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Intracellular calcium and cAMP regulate directional pigment movements in teleost erythrophores.细胞内钙和环磷酸腺苷调节硬骨鱼红色素细胞中的色素定向移动。
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3
cAMP signaling in neurons: patterns of neuronal expression and intracellular localization for a novel protein, AKAP 150, that anchors the regulatory subunit of cAMP-dependent protein kinase II beta.
神经元中的环磷酸腺苷（cAMP）信号传导：一种新型蛋白AKAP 150的神经元表达模式及细胞内定位，该蛋白可锚定环磷酸腺苷依赖性蛋白激酶IIβ的调节亚基。
Mol Biol Cell. 1992 Nov;3(11):1215-28. doi: 10.1091/mbc.3.11.1215.