Boltin Doron, Niv Yaron
Department of Gastroenterology, Rabin Medical Center (Beilinson Campus), Petah Tikva, Israel.
Isr Med Assoc J. 2012 Feb;14(2):130-2.
Eradication of Helicobacter pylori is accompanied by an array of metabolic and hormonal changes in the host. Weight gain following H. pylori eradication is a poorly understood phenomenon and probably results from an interaction between multiple factors. Ghrelin, a peptide hormone secreted by the stomach, is involved in the regulation of food intake and appetite and may account for some of these changes. Although several observational studies have demonstrated that H. pylori infection suppresses circulating ghrelin levels, it has yet to be proven that ghrelin levels increase following eradication. On the other hand, gastric expression of ghrelin, also suppressed by H. pylori, clearly increases following eradication. The determinants of plasma ghrelin levels remain elusive, as do the effects of eradication on these levels. Weight gain following H. pylori eradication may be attributable to changes in plasma and gastric ghrelin; however, this hypothesis needs to be further investigated.
根除幽门螺杆菌会伴随宿主一系列代谢和激素变化。幽门螺杆菌根除后体重增加是一个尚未被充分理解的现象，可能是多种因素相互作用的结果。胃饥饿素是一种由胃分泌的肽类激素，参与食物摄入和食欲的调节，可能是这些变化的部分原因。尽管多项观察性研究表明幽门螺杆菌感染会抑制循环中的胃饥饿素水平，但根除幽门螺杆菌后胃饥饿素水平是否升高尚未得到证实。另一方面，同样被幽门螺杆菌抑制的胃饥饿素的胃表达，在根除后明显增加。血浆胃饥饿素水平的决定因素仍然难以捉摸，根除幽门螺杆菌对这些水平的影响也是如此。幽门螺杆菌根除后体重增加可能归因于血浆和胃中胃饥饿素的变化；然而，这一假设需要进一步研究。
