Nutrition and Endocrine Research Center and Obesity Research Center, Research Institute for Endocrine Sciences, Tehran, Iran.
Department of Clinical Nutrition and Diet Therapy, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Tehran, Iran.
Endocrinol Metab (Seoul). 2015 Sep;30(3):280-7. doi: 10.3803/EnM.2015.30.3.280. Epub 2015 May 18.
Helicobacter pylori infection and subsequent gastric inflammation have been proposed as risk factors for the development of insulin resistance and cardiovascular disease. In this study we assessed the possible association of H. pylori bacterial load, and serum biomarker of gastric inflammation with cardiometabolic risk factors in diabetic patients.
In this cross-sectional study, 84 H. pylori-infected type 2 diabetic patients were assessed for anthropometrics, biochemical and clinical measurements. Pearson correlation test, linear, and logarithmic regression curve estimation models were used to assess the association of H. pylori stool antigen (HpSAg) levels, and pepsinogen I (PGI) to pepsinogen II (PGII) ratio with fasting serum glucose, insulin, serum lipid and lipoprotein parameters, malondialdehyde, high-sensitive C-reactive protein (hs-CRP), systolic and diastolic blood pressure, body weight, waist circumference and lipid accumulation product (LAP) index.
The mean age of participants was 54±10 years, and 44% were men. Mean HpSAg levels and PGI/PGII ratio were 0.24±0.23 μg/mL and 9.9±9.0, respectively. Higher HpSAg as well as lower PGI/PGII was correlated with higher anthropometric measures and LAP. A significant negative correlation between PGI/PGII ratio and blood pressure (r=-0.21 and r=-0.22, systolic and diastolic, respectively, P<0.05), serum insulin (r=-0.17, P=0.05), and hs-CRP (r=-0.17, P=0.05) was observed. A significant linear association between PGI/PGII ratio with serum triglycerides (γ=-0.24, P<0.05), serum high density lipoprotein cholesterol (HDL-C; γ=0.43, P<0.01), and triglycerides/HDL-C ratio (γ=-0.28, P<0.05) were observed.
Higher H. pylori bacterial load and lower PGI/PGII ratio was associated with higher levels of cardiometabolic risk factors in H. pylori infected type 2 diabetic patients.
幽门螺杆菌感染和随后的胃炎症被认为是导致胰岛素抵抗和心血管疾病发展的危险因素。在这项研究中，我们评估了幽门螺杆菌细菌负荷和胃炎症的血清生物标志物与糖尿病患者的心血管代谢危险因素之间的可能关联。
在这项横断面研究中，评估了 84 例幽门螺杆菌感染的 2 型糖尿病患者的人体测量学、生化和临床测量值。使用 Pearson 相关检验、线性和对数回归曲线估计模型来评估幽门螺杆菌粪便抗原 (HpSAg) 水平和胃蛋白酶原 I (PGI) 与胃蛋白酶原 II (PGII) 的比值与空腹血清葡萄糖、胰岛素、血清脂质和脂蛋白参数、丙二醛、高敏 C 反应蛋白 (hs-CRP)、收缩压和舒张压、体重、腰围和脂质堆积产物 (LAP) 指数之间的关系。
参与者的平均年龄为 54±10 岁，其中 44%为男性。平均 HpSAg 水平和 PGI/PGII 比值分别为 0.24±0.23 μg/mL 和 9.9±9.0。较高的 HpSAg 以及较低的 PGI/PGII 与较高的人体测量学指标和 LAP 相关。HpSAg 与血压 (r=-0.21 和 r=-0.22，收缩压和舒张压，分别，P<0.05)、血清胰岛素 (r=-0.17，P=0.05) 和 hs-CRP (r=-0.17，P=0.05) 呈显著负相关。PGI/PGII 比值与血清三酰甘油 (γ=-0.24，P<0.05)、血清高密度脂蛋白胆固醇 (HDL-C；γ=0.43，P<0.01) 和三酰甘油/HDL-C 比值 (γ=-0.28，P<0.05) 之间存在显著线性关联。
在幽门螺杆菌感染的 2 型糖尿病患者中，较高的幽门螺杆菌细菌负荷和较低的 PGI/PGII 比值与较高的心血管代谢危险因素水平相关。
