Szatmari P, Saigal S, Rosenbaum P, Campbell D, King S
Department of Psychiatry, McMaster University, Hamilton, Ontario, Canada.
Dev Med Child Neurol. 1990 Nov;32(11):954-62.
The relationship between extremely low birthweight (ELBW) and psychiatric disorder was investigated in a cohort of children of 500 to 1000g birthweight, born between 1980 and 1982. At five years of age data were collected for 82 of 90 survivors on psychiatric symptoms, parent-reported developmental delay and various aspects of psychosocial disadvantage. Compared with controls, ELBW children did not come from more disadvantaged environments, but were much more likely to experience developmental delay and problems with motor co-ordination. 16 per cent had an attention deficit disorder with hyperactivity (ADDH), compared with 6.9 per cent of controls. Rates of conduct disorder and emotional disorder were not raised, indicating that ELBW is a specific risk factor for ADDH. Controlling for the effect of neurodevelopmental problems rendered the association between ELBW and ADDH non-significant.
对1980年至1982年间出生体重在500至1000克之间的一组儿童进行了极低出生体重（ELBW）与精神疾病之间关系的调查。在五岁时，对90名幸存者中的82名收集了有关精神症状、家长报告的发育迟缓以及心理社会不利因素各方面的数据。与对照组相比，ELBW儿童并非来自更不利的环境，但更有可能经历发育迟缓以及运动协调问题。16%的儿童患有注意力缺陷多动障碍（ADDH），而对照组为6.9%。品行障碍和情绪障碍的发生率并未升高，这表明ELBW是ADDH的一个特定风险因素。控制神经发育问题的影响后，ELBW与ADDH之间的关联变得不显著。
