Institute of Life Science, Jiangsu University, Zhenjiang, Jiangsu, 212013, P.R. China.
J Biomol Struct Dyn. 2012;30(4):407-18. doi: 10.1080/07391102.2012.682207. Epub 2012 Jun 12.
In the present study, a comprehensive analysis of the arginase gene family in metazoans was performed. A total of 126 arginase genes have been identified in 44 species. Phylogenetic analyses indicate that arginase genes consist of four groups. Conservative and divergent gene structures are found among the groups. The syntenies also exist in distantly related genomes among multiple species. Adaptive evolution shows that, while purifying selection may have been the main force driving the evolution of the arginases, some of critical sites responsible for the functional divergence may have been under positive selection. Overall, the data obtained from our investigation contribute to a better understanding of the complexity of the arginase gene family and of the function and evolution of this family in metazoans.
在本研究中，对后生动物的精氨酸酶基因家族进行了全面分析。在 44 个物种中鉴定出了 126 个精氨酸酶基因。系统发育分析表明，精氨酸酶基因由四个组组成。组间存在保守和分歧的基因结构。在多个物种的远缘基因组中也存在基因同线性。适应性进化表明，虽然纯化选择可能是驱动精氨酸酶进化的主要力量，但一些负责功能分歧的关键位点可能受到正选择的影响。总的来说，我们研究获得的数据有助于更好地理解精氨酸酶基因家族的复杂性，以及该家族在后生动物中的功能和进化。
