针对Rh系统C、c、E、e和G抗原的人单克隆抗体。
Human monoclonal antibodies to C, c, E, e and G antigens of the Rh system.
作者信息
Thompson K, Barden G, Sutherland J, Beldon I, Melamed M
机构信息
Department of Biochemistry, Polytechnic of East London.
出版信息
Immunology. 1990 Nov;71(3):323-7.
Abstract
A panel of heterohybridomas secreting human IgG and IgM monoclonal antibodies to the C, c, G, E, and e antigens of the Rh system has been established. Both classes of antibody have been shown to react with red blood cells carrying their respective antigens; those of the IgM class being able to directly agglutinate unmodified red blood cells in saline. The heterohybridomas have been shown to be suitable for bulk culture and produce levels of antibody in the range of 15-73 micrograms/ml in the spent culture supernatant.
摘要
已建立了一组分泌针对Rh系统C、c、G、E和e抗原的人IgG和IgM单克隆抗体的异种杂交瘤。已证明这两类抗体均能与携带各自抗原的红细胞发生反应；IgM类抗体能够在盐水中直接凝集未修饰的红细胞。已证明这些异种杂交瘤适合大规模培养，在培养上清液中产生的抗体水平为15 - 73微克/毫升。
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