Department of Gynecology and Obstetrics, Comprehensive Cancer Center, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
Eur J Cancer Prev. 2013 Jan;22(1):52-8. doi: 10.1097/CEJ.0b013e328355ec22.
Estrogen exposure has at least a moderate effect on the risk for ovarian cancer, and antiestrogen therapy may be helpful in treating the disease. It is known from breast cancer that previous hormone replacement therapy (HRT) may influence the molecular profile and prognostic behavior of these tumors. The aim of this study was therefore to investigate the influence of previous HRT on the prognosis in a cohort of patients with invasive epithelial ovarian cancer. Among 547 patients who were treated for ovarian malignancies at a single institution from 1995 to 2008, a total of 244 postmenopausal patients with epithelial cancer and under the age of 75 were identified for whom information about HRT before the onset of the disease was available. HRT was correlated with tumor and patient characteristics. Analyses of overall survival and progression-free survival were carried out using Cox proportional hazards models. Age, tumor stage, and resection status correlated significantly with HRT in the univariate analysis. Patients with previous HRT were more likely to have a lower stage, to be younger, and to have optimal debulking. With regard to survival, HRT had a positive effect on overall survival, specifically in the subgroup of patients with optimal debulking. No correlation was seen in relation to progression-free survival. Sex hormone exposure through HRT may influence the behavior of ovarian cancers after the onset of the disease. This study supports the hypothesis that ovarian cancer is a hormonally influenced tumor.
雌激素暴露至少对卵巢癌风险有中度影响，抗雌激素治疗可能有助于治疗该疾病。从乳腺癌可知，先前的激素替代疗法（HRT）可能会影响这些肿瘤的分子特征和预后行为。因此，本研究旨在调查先前的 HRT 对一组患有侵袭性上皮性卵巢癌患者的预后的影响。在 1995 年至 2008 年在一家机构治疗卵巢恶性肿瘤的 547 名患者中，共确定了 244 名绝经后患有上皮性癌症且年龄小于 75 岁的患者，这些患者在疾病发作前有关于 HRT 的信息。将 HRT 与肿瘤和患者特征相关联。使用 Cox 比例风险模型对总生存期和无进展生存期进行分析。在单因素分析中，年龄、肿瘤分期和切除状态与 HRT 显著相关。接受过 HRT 的患者更有可能处于较低的分期、更年轻，并且接受了最佳的肿瘤细胞减灭术。就生存而言，HRT 对总生存期有积极影响，特别是在最佳肿瘤细胞减灭术的患者亚组中。与无进展生存期无关。通过 HRT 进行的性激素暴露可能会影响疾病发作后卵巢癌的行为。本研究支持卵巢癌是一种受激素影响的肿瘤的假说。
