人类肾移植中淋巴细胞Fcγ受体阻断因子的体外研究
In vitro studies on lymphocyte Fc gamma receptor blocking factors in human renal transplantation.
作者信息
Sandilands G P, Highet J, Degiannis D, McMillan M A, Junor B J, Briggs J D, MacSween R N
机构信息
University Department of Pathology, Western Infirmary, Glasgow, U.K.
出版信息
Immunol Lett. 1990 Nov;26(2):153-7. doi: 10.1016/0165-2478(90)90138-g.
PMID:2269485
Abstract
In this study we have confirmed our earlier observation that the presence in pre-transplant serum of a high-molecular-weight lymphocyte Fc gamma receptor blocking factor correlates with improved human renal allograft survival. This factor was found to bind preferentially to B cells and to impair B cell function in vitro.
摘要
在本研究中，我们证实了我们早期的观察结果，即移植前血清中存在高分子量淋巴细胞Fcγ受体阻断因子与人类肾移植存活率的提高相关。发现该因子优先结合B细胞并在体外损害B细胞功能。
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