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[C2 骨巨细胞瘤合并动脉瘤样骨囊肿。病例报告]

[Giant cell tumor of the C2 colonized by an aneurismal bone cyst. Report of case].

作者信息

Cebula H, Boujan F, Beaujeux R, Boyer P, Froelich S

机构信息

Service de neurochirurgie, hôpital de Hautepierre - hôpitaux universitaires de Strasbourg, 67098 Strasbourg, France.

出版信息

Neurochirurgie. 2012 Dec;58(6):376-81. doi: 10.1016/j.neuchi.2012.03.008. Epub 2012 Jun 12.

Abstract

Giant cell tumor is colonized by aneurismal bone cyst in only 15% of cases and cervical localisation accounts for less than 1% of giant cell tumors. We are reporting a rare case of a C2 hypervascularized giant cell tumor colonized by an aneurismal bone cyst treated with an effective preoperative Onyx embolization followed by a full tumor resection. The patient experienced a moderate cervical spine injury 2 months prior admission followed by a progressive stiff neck and cervicalgia. CT and MRI identified a lytic lesion of the body and lateral masses of the C2 with encasement of both vertebral arteries. The angiography showed a hypervascularization of the lesion from the vertebral and external carotid arteries as well as a thrombosis of the V3 segment of the right vertebral artery at the C1 level. A posterior occipito-C3/C4 fixation and a tumor biopsy were performed. Histopathological examination concluded to a giant cell tumor colonized by an aneurismal bone cyst. Three weeks later, the patient developed a right upper extremity deficit. The MRI showed an increased C1-C2 stenosis and an increase of the hypervascularization. Three sessions of embolization by the onyx were performed. During surgery a near total tumor devascularisation was observed and a complete resection of the tumor was achieved through an anterolateral approach. Reconstruction consisted of a cementoplasty of the C2 body and odontoïd process with an anterior C3-prosthesis plate. The postoperative course was uneventful.

摘要

骨巨细胞瘤仅在15%的病例中合并动脉瘤样骨囊肿,而颈椎部位的骨巨细胞瘤占比不到1%。我们报告了一例罕见的C2节段高度血管化骨巨细胞瘤合并动脉瘤样骨囊肿的病例,该患者术前接受了有效的Onyx栓塞治疗,随后进行了肿瘤全切术。患者在入院前2个月经历了中度颈椎损伤,随后出现进行性颈部僵硬和颈痛。CT和MRI检查发现C2椎体及侧块有溶骨性病变,双侧椎动脉被包绕。血管造影显示病变由椎动脉和颈外动脉供血,右侧椎动脉C1水平V3段血栓形成。进行了枕后C3/C4固定及肿瘤活检。组织病理学检查确诊为骨巨细胞瘤合并动脉瘤样骨囊肿。三周后,患者出现右上肢功能障碍。MRI显示C1-C2狭窄加重,血管化增加。进行了三次Onyx栓塞治疗。手术中观察到肿瘤几乎完全去血管化,通过前外侧入路实现了肿瘤全切。重建包括C2椎体及齿突骨水泥成形术,并用前路C3假体钢板固定。术后恢复顺利。

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