一个高度带电的电压传感器螺旋体自动穿过膜进行移位。
A highly charged voltage-sensor helix spontaneously translocates across membranes.
机构信息
Biochemistry, Tulane University School of Medicine, New Orleans, LA 70112, USA.
出版信息
Angew Chem Int Ed Engl. 2012 Jul 16;51(29):7150-3. doi: 10.1002/anie.201202741. Epub 2012 Jun 13.
Abstract
Moving freely: A recent model for voltage gating of potassium channels proposed that the four arginine residues of the voltage-sensing S4 helix (left) are in direct contact with the membrane lipids and move into the hydrocarbon core of the membrane during gating. It is demonstrated that the physical properties of the isolated S4 sequence (right) are sufficient to allow it to freely translocate across synthetic membranes.
摘要
自由移动
最近提出的钾通道电压门控模型表明，电压感应 S4 螺旋（左）的四个精氨酸残基与膜脂直接接触，并在门控过程中移动到膜的烃核中。实验证明，分离的 S4 序列（右）的物理性质足以使其自由穿过合成膜。
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