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预防尿路结石的水。

Water for preventing urinary stones.

作者信息

Bao Yige, Wei Qiang

机构信息

Department of Urology, West China Hospital, Sichuan University, Chengdu, China.

出版信息

Cochrane Database Syst Rev. 2012 Jun 13(6):CD004292. doi: 10.1002/14651858.CD004292.pub3.

Abstract

BACKGROUND

Urinary stones are a common condition characterised by high incidence and high recurrence rate. For a long time, increased water intake has been the main preventive measure for the disease and its recurrence. This is an update of a review originally published in 2004.

OBJECTIVES

To assess the effectiveness of increased water intake for the primary and secondary prevention of urinary stones.

SEARCH METHODS

We searched the Cochrane Renal Group's specialised register, CENTRAL, MEDLINE, EMBASE, and the Chinese Biomedical Disk using a search strategy developed in conjunction with Cochrane Renal Group's Trials Search Co-ordinator. No language restriction was applied. Date of last search: April 2012.

SELECTION CRITERIA

Randomised controlled trials (RCTs) and quasi-RCTs of increased water intake for the prevention of urinary stones and its recurrence were included.

DATA COLLECTION AND ANALYSIS

Two authors independently assessed risk of bias and extracted data. Statistical analyses were performed using the random effects model and the results expressed as risk ratio (RR) for dichotomous outcomes or mean difference (MD) for continuous data with 95% confidence intervals (CI).

MAIN RESULTS

No studies of increased water intake for the primary prevention of urinary stones met the inclusion criteria. One study with 199 patients provided results of increased water intake for the recurrence of urinary stones. The stone recurrence was lower in the increased water intake group than that of the no intervention group (12% versus 27%; RR 0.45, 95% CI 0.24 to 0.84). The average interval for recurrence was 3.23 ± 1.1 years in increased water intake group and 2.09 ± 1.37 years in the no intervention group (MD 1.14, 95% CI 0.33 to 1.95). There were insufficient data to assess selection, performance, detection or attrition bias.

AUTHORS' CONCLUSIONS: The evidence from only one study indicates that increased water intake reduces the risk of recurrence of urinary stones and prolongs the average interval for recurrences. However further research is required. Due to the lack of appropriate RCTs, no conclusions can be drawn on increased water intake for the primary and secondary prevention of urinary stones.

摘要

背景

尿路结石是一种常见疾病,具有高发病率和高复发率的特点。长期以来,增加饮水量一直是预防该疾病及其复发的主要措施。这是对一篇最初发表于2004年的综述的更新。

目的

评估增加饮水量对尿路结石一级和二级预防的有效性。

检索方法

我们使用与Cochrane肾脏组试验检索协调员共同制定的检索策略,检索了Cochrane肾脏组专业注册库、CENTRAL、MEDLINE、EMBASE以及中国生物医学数据库。未设语言限制。最后检索日期:2012年4月。

选择标准

纳入了关于增加饮水量预防尿路结石及其复发的随机对照试验(RCT)和半随机对照试验。

数据收集与分析

两位作者独立评估偏倚风险并提取数据。采用随机效应模型进行统计分析,结果以二分变量结局的风险比(RR)或连续数据的均值差(MD)表示,并给出95%置信区间(CI)。

主要结果

没有关于增加饮水量用于尿路结石一级预防的研究符合纳入标准。一项纳入199例患者的研究提供了增加饮水量对尿路结石复发影响的结果。增加饮水量组的结石复发率低于无干预组(12%对27%;RR 0.45,95%CI 0.24至0.84)。增加饮水量组的平均复发间隔为3.23±1.1年,无干预组为2.09±1.37年(MD 1.14,95%CI 0.33至1.95)。评估选择、实施、检测或失访偏倚的数据不足。

作者结论

仅一项研究的证据表明,增加饮水量可降低尿路结石复发风险并延长平均复发间隔。然而,仍需要进一步研究。由于缺乏合适的随机对照试验,无法就增加饮水量用于尿路结石一级和二级预防得出结论。

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