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与去羟肌苷相关的肝脏结节性再生性增生即使在停药后仍会持续数年。

Nodular regenerative hyperplasia of the liver associated with didanosine persists for years even after its interruption.

作者信息

Hofmaenner Daniel, Kovari Helen, Weber Achim, Weishaupt Dominik, Speck Roberto F

机构信息

Medical School, University of Zurich, Zurich, Switzerland.

出版信息

BMJ Case Rep. 2011 May 3;2011:bcr0320113928. doi: 10.1136/bcr.03.2011.3928.

DOI:10.1136/bcr.03.2011.3928
PMID:22696691
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3089926/
Abstract

The authors describe an HIV-positive patient with nodular regenerative hyperplasia of the liver with non-cirrhotic portal hypertension. Despite stopping the culprit drug, didanosine, the radiologic changes persisted for years. When evaluating liver pathologies, antiretroviral drugs must be included in the differential diagnosis, even when they have been stopped years ago.

摘要

作者描述了一名HIV阳性患者,患有肝脏结节性再生性增生伴非肝硬化性门静脉高压症。尽管停用了致病药物去羟肌苷,但影像学改变持续了数年。在评估肝脏病变时,抗逆转录病毒药物必须纳入鉴别诊断,即使它们在数年前就已停用。

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Nodular regenerative hyperplasia of the liver associated with didanosine persists for years even after its interruption.与去羟肌苷相关的肝脏结节性再生性增生即使在停药后仍会持续数年。
BMJ Case Rep. 2011 May 3;2011:bcr0320113928. doi: 10.1136/bcr.03.2011.3928.
2
[Non-cirrhotic portal hypertension due to didanosina. A rare case].[齐多夫定所致非肝硬化性门静脉高压症。1例罕见病例]
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本文引用的文献

1
Association of noncirrhotic portal hypertension in HIV-infected persons and antiretroviral therapy with didanosine: a nested case-control study.HIV感染者中非肝硬化门静脉高压症与抗逆转录病毒治疗使用去羟肌苷的关联:一项巢式病例对照研究。
Clin Infect Dis. 2009 Aug 15;49(4):626-35. doi: 10.1086/603559.
2
Noncirrhotic portal hypertension in patients with human immunodeficiency virus-1 infection.人类免疫缺陷病毒1型感染患者的非肝硬化门静脉高压症
Clin Gastroenterol Hepatol. 2008 Oct;6(10):1167-9. doi: 10.1016/j.cgh.2008.04.023. Epub 2008 Jul 17.
3
Nodular regenerative hyperplasia is a new cause of chronic liver disease in HIV-infected patients.结节性再生性增生是HIV感染患者慢性肝病的一个新病因。
AIDS. 2007 Jan 11;21(2):187-92. doi: 10.1097/QAD.0b013e3280119e47.
4
Nodular regenerative hyperplasia: not all nodules are created equal.结节性再生性增生:并非所有结节都是一样的。
Hepatology. 2006 Jul;44(1):7-14. doi: 10.1002/hep.21258.
5
Nodular regenerative hyperplasia: a reversible entity associated with azathioprine therapy.结节性再生性增生:一种与硫唑嘌呤治疗相关的可逆性病变。
Eur J Gastroenterol Hepatol. 2006 May;18(5):553-5. doi: 10.1097/00042737-200605000-00018.
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A multicenter assessment of liver toxicity by MRI and biopsy in IBD patients on 6-thioguanine.一项针对接受6-硫鸟嘌呤治疗的炎症性肠病(IBD)患者,通过磁共振成像(MRI)和活检进行肝毒性的多中心评估。
J Hepatol. 2005 Aug;43(2):303-9. doi: 10.1016/j.jhep.2005.02.051.
7
Significance of magnetic resonance imaging in the diagnosis of nodular regenerative hyperplasia of the liver complicated with systemic lupus erythematosus: a case report and review of the literature.磁共振成像在诊断合并系统性红斑狼疮的肝脏结节性再生性增生中的意义:一例报告并文献复习
Lupus. 2002;11(3):193-6. doi: 10.1191/0961203302lu164cr.
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Nodular regenerative hyperplasia of the liver in Budd-Chiari syndrome: CT and MR features.布加综合征中肝脏的结节性再生性增生:CT与MR表现
Abdom Imaging. 2000 May-Jun;25(3):255-8. doi: 10.1007/s002610000027.
9
Didanosine: an updated review of its use in HIV infection.去羟肌苷:其在HIV感染治疗中应用的最新综述。
Drugs. 1999 Dec;58(6):1099-135. doi: 10.2165/00003495-199958060-00009.
10
Pseudotumoral presentation of nodular regenerative hyperplasia of the liver: imaging in five patients including MR imaging.肝脏结节性再生性增生的假瘤样表现:5例患者的影像学表现,包括磁共振成像
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